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SYNTHESIS AND CONFIGURATION OF DIASTEREOMERIC 2,4-, 2,5-, AND 2,6-PIPERIDINEDICARBOXYLIC ACIDS AND THEIR DIMETHYL ESTERS
Mastafanova, L. I.,Turchin, K. F.,Evstratova, M. I.,Sheinker, Yu. N.,Yakhontov, L. N.
, p. 305 - 309 (1985)
The reduction in an acidic medium over a platinum catalysts of 2,4-, 2,5-, and 2,6-pyridinedicarboxylic acids gave cis-2,4-, -2,5-, and -2,6-piperidinedicarboxylic acids, heating of which in an alkaline medium led to thermodynamically equilibrium mixtures of diastereomers.Individual trans-2,5-piperidinecarboxylic acid was isolated.The configurations of the 2,4-, 2,5-, and 2,6-piperidinedicarboxylic acids and their methyl esters were established by means of the PMR spectra.
