84230-77-3Relevant academic research and scientific papers
TOTAL SYNTHESIS OF 5-DESOXYLEUKOTRIENE D. A NEW AND USEFUL EQUIVALENT OF THE 4-FORMYL-TRANS,TRANS-1,3-BUTADIENYL ANION
Corey, E. J.,Hoover, Dennis J.
, p. 3463 - 3466 (2007/10/02)
The first total synthesis of 5-desoxyleukotriene D (14) is reported.The route of synthesis utilizes a novel method for five-carbon chain extension.The availability of 14 allowed experimental demonstration that the 5-hydroxyl function is important for biological activity of the slow reacting substances.
