84271-84-1Relevant articles and documents
Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes
Xing, Yidan,Yu, Rongrong,Fang, Xianjie
, p. 1008 - 1012 (2020/02/04)
The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the-OH and-NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.
P(i-BuNCH2CH2)3N: An efficient ligand for the direct α-arylation of nitriles with aryl bromides
You, Jingsong,Verkade, John G.
, p. 8003 - 8007 (2007/10/03)
A new catalyst system for the synthesis of α-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH 2CH2)3N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct α-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.
Thermodynamic Control of Regioselectivity in the Addition of Carbanions to (Arene)tricarbonylchromium Complexes
Kuendig, E. Peter,Desobry, Vincent,Simmons, Dana P.,Wenger, Eric
, p. 1804 - 1815 (2007/10/02)
The results of a study of question of kinetic or thermodynamic control of the addition of carbon nucleophiles to (arene)Cr(CO)3 complexes are presented. 2-Lithio-2-methylpropionitrile (1) is shown to add reversibly to (naphthalene)Cr(CO)3 (2), (5,8-dimeth
