84305-41-9

Usage

Uses

Used in Healthcare Industry:
CEFMINOX is used as an antibiotic for treating various bacterial infections due to its broad-spectrum efficacy. It is particularly effective for infections of the respiratory tract, urinary tract, skin, and soft tissues. The injectable form of CEFMINOX is commonly administered in hospital settings for serious infections, ensuring that it is used under the guidance of healthcare professionals to minimize the risk of antibiotic resistance development.

Upstream product

• 24209-38-9 (6R,7R)-7-amino-3-[(1H-1-methyltetrazol-5-yl)thio]methylceph-3-em-4-carboxylic acid 
• 32443-99-5 D-cysteine hydrochloride 
• 598-21-0 2-Bromoacetyl bromide 
• 921-01-7 D-cysteine 

Relevant academic research and scientific papers

7-MAC, preparation method therefor and synthesis method for cefminox sodium

The invention provides 7-MAC. The 7-MAC has a chemical structure represented by a formula I shown in the description. The invention further provides a preparation method for the 7-MAC and applicationof the 7-MAC and a synthesis method for cefminox sodium. According to the 7-MAC and the synthesis method, provided by the invention, the reaction conditions of preparation of cynnematin (e.g. cefminoxsodium) are simplified, the operability is improved, and meanwhile, the cost is reduced, so that the cynnematin has obvious competitive advantage.

Synthesis method of cefminox sodium

The invention aims at providing a synthesis method of cefminox sodium. The synthesis method specifically comprises the following steps: firstly, mixing 7beta-amino-7alpha-methoxy-3-[(1-methyl-1H-5-tetrazolyl)-mercapto methyl]-3-cephem-4-methyl diphenyl carboxylate and dichloromethane (7-MAC), and bromoacetamide bromine under a certain condition to obtain 7beta-bromoacetyl amino-7alpha-methoxy-3-[(1-methyl-1H-5-tetrazolyl)-mercapto methyl]-3-cephem-4-methyl diphenyl carboxylate; then removing a carboxylic acid protection group to obtain 7beta-bromoacetyl amino-7alpha-methoxy-3-[(1-methyl-1H-5-tetrazolyl)-mercapto methyl]-3-cephem-4-carboxylic acid; then enabling the 7beta-bromoacetyl amino-7alpha-methoxy-3-[(1-methyl-1H-5-tetrazolyl)-mercapto methyl]-3-cephem-4-carboxylic acid to react withD-cysteine hydrochloride to obtain the cefminox sodium. According to the synthesis method provided by the invention, the product yield and purity of the synthesized cefminox sodium are high; phosphoric acid loaded activated carbon is used as a solid catalyst and is easy to separate from a reaction system, and the formation of acid waste liquid is avoided.