84319-43-7

Basic information

• Product Name: 1,3,4-Oxadiazole, 2-methyl-5-(phenylmethyl)-
• CAS NO: 84319-43-7
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Mol File: 84319-43-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,3,4-Oxadiazole, 2-methyl-5-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Oxadiazole, 2-methyl-5-(phenylmethyl)-(84319-43-7)
• EPA Substance Registry System: 1,3,4-Oxadiazole, 2-methyl-5-(phenylmethyl)-(84319-43-7)

Safety Data

• Hazardous Substances Data: 84319-43-7(Hazardous Substances Data)

Upstream product

• 4695-09-4 α-mercaptophenylacetic acid 
• 611-71-2 MANDELIC ACID 
• 16201-52-8 2-mercapto-2-phenylacetic acid methyl ester 
• 90006-97-6 α-mercaptophenylacetic acid hydrazide 
• 78-39-7 Triethyl orthoacetate 
• 1372151-69-3 N2-(1-ethoxyethylidene)-α-mercaptophenylacetic acid hydrazide 
• 4870-65-9 2-bromophenylacetic acid 
• 937-39-3 2-phenylacetylhydrazine 
• 73818-55-0 Bestmann ylide 
• 18489-25-3 5-benzyl-1H-tetrazole 
• 108-24-7 acetic anhydride 
• 26404-64-8 phenyl-acetic acid ethylidenehydrazide 
• 18489-25-3 5-benzyl-2H-tetrazole 
• 75-36-5 acetyl chloride 

Relevant articles and documents

Reactions of α-mercaptocarboxylic acid hydrazides with triethyl orthoesters: Synthesis of 1,3,4-thiadiazin-5(6H)-ones and 1,3,4-oxadiazoles

Reactions of α-mercapto-β-phenylpropionic and α-mercaptophenylacetic acid hydrazides with triethyl orthoesters were conducted under N2 in glacial acetic acid and resulted in the formation of two groups of products, derivatives of 1,3,4-thiadiazin-5(6H)-ones and 2-(1-mercaptomethyl)-1,3,4-oxadiazoles. When conducting the same transformations on α-mercaptophenylacetic acid hydrazide in the presence of air, two different products from the 1,3,4-oxadiazole family, the appropriate bis(1,3,4-oxadiazol-2-yl-phenylmethyl) disulfides and 2-benzyl-1,3,4- oxadiazoles, were formed with the liberation of free sulfur. The oxygenated bis(1,3,4-oxadiazol-2-yl-phenylmethyl) disulfides were reduced to the corresponding 2-(1-mercaptomethyl)-1,3,4-oxadiazoles with the use of zinc powder under mild conditions.

The application of cross-linked poly[styrene(iodoso diacetate)] to the synthesis of 1,3,4-oxadiazoles

The 2% cross-linked poly[styrene(iodosodiacetate)] has been synthesized, and has been applied effectively to the synthesis of 1,3,4-oxadiazole derivatives, and regenerated and reused for the same reaction.

TETRAZOLES IN THE SYNTHESES OF 1,3,4-OXADIAZOLES

Various variants of cleavage of tetrazoles to form 1,3,4-oxadiazoles are examined.The mechanisms and synthetic potentialities of these reactions are discussed.