84341-94-6

Upstream product

• 72657-23-9 methyl (R)-3-hydroxy-2-methylpropionate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 60148-95-0 (R)-2,6-dimethylheptanoic acid methyl ester 
• 1442105-08-9 C₁₂H₁₅IO₃S 
• 121749-23-3 Toluene-4-sulfonic acid (S)-3-hydroxy-2-methyl-propyl ester 
• 148290-12-4 (R)-2-Methyl-3-(p-toluenesulfonate)-propanal diethyl acetal 
• 182486-32-4 (R)-methyl 3-{[(tert-butoxy)carbonyl]amino}-2-methylpropionate 
• 84506-41-2 methyl (2R)-3-azido-2-methylpropanoate 
• 86961-08-2 methyl (S)-(-)-3-acetyl-thio-2-methylpropanoate 

Relevant academic research and scientific papers

Asymmetric syntheses of potent antitumor macrolides cryptophycin B and arenastatin A

Efficient and highly stereoselective syntheses of cryptophycin B and arenastatin A, potent cytotoxic agents, are described. An ester-derived titanium enolate mediated syn-aldol reaction was employed to generate the stereocenters C-5 and C-6. The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycins as well as members of its family. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

Oligomers of N-Substituted β2-Homoalanines: Peptoids with Backbone Chirality

A new class of peptoid-based peptidomimetics composed of oligomers of N-substituted β2-homoalanines is reported. Design, solid-phase synthesis, and preliminary circular dichroism studies of oligomers of N-alkylated β2-homoalanines co

SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS

The present description relates to substituted polycyclic compounds and forms and pharmaceutical compositions thereof and methods of using such compounds, forms or compositions thereof for treating or ameliorating Neisseria gonorrhoeae and Neisseria meningiditis.

A concise total synthesis of amphidinolide T2

RCM+AD=T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required

A convergent synthesis of (+)-cryptophycin B, a potent antitumor macrolide from Nostoc sp. cyanobacteria.

[structure--see text] An efficient and highly stereoselective synthesis of cryptophycin B (2), a potent cytotoxic agent, is described. The ester-derived titanium-enolate-mediated syn-aldol reaction was employed to generate the stereocenters C(5) and C(6). The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycin B as well as members of its family.

Easy access to both enantiomers of C7-C12 segment of epothilones

Both enantiomers of the C7-C12 segment (5 and 6) of epothilones A and B (1 and 2) were effectively synthesized starting from the methyl (R)- and (S)- hydroxy-2-methylpropionates (3 and 4) using the Grignard cross-coupling reaction mediated by cuprous (I)

Antiviral and Antitumor Structure-Activity Relationship Studies on Tetracyclic Eudistomines

The in vitro antiviral and antitumor activities of (-)-debromoeudistomin K (1a) and 10 structural analogues (1b-1j and 11) were evaluated.The synthesis was accomplished with an intramolecular Pictet-Spengler condensation reaction as the key step.This exam