84370-87-6

Basic information

• Product Name: 2,4-DIMETHOXYPHENYL ISOCYANATE
• Synonyms: 2,4-DIMETHOXYPHENYL ISOCYANATE;Benzene, 1-isocyanato-2,4-dimethoxy- (9CI);2,4-Dimethoxyphenyl;2,4-Dimethoxyphenyl isocyanate,97%;2,4-DiMethoxyphenyl isocyanate, 97% 1GR;2,4-DiMethoxyphenyl isocyanate, 97% 5GR;Benzene, 1-isocyanato-2,4-dimethoxy-
• CAS NO: 84370-87-6
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17
• EINECS: 282-747-4
• Product Categories: ISOCYANATE;Isocyanates;Nitrogen Compounds;Organic Building Blocks
• Mol File: 84370-87-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 31-32°C
• Boiling Point: 139-141°C 11mm
• Flash Point: >110°C
• Appearance: Clear light yellow/Liquid After Melting
• Density: 1.2822 (rough estimate)
• Vapor Pressure: 0.00568mmHg at 25°C
• Refractive Index: 1.5465-1.5485
• Sensitive: Moisture Sensitive
• BRN: 1106649
• CAS DataBase Reference: 2,4-DIMETHOXYPHENYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXYPHENYL ISOCYANATE(84370-87-6)
• EPA Substance Registry System: 2,4-DIMETHOXYPHENYL ISOCYANATE(84370-87-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22-42
• Safety Statements: 36/37/39-26
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 84370-87-6(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid after melting

Uses

2,4-Dimethoxyphenyl isocyanate has been used in the preparation of pyrrolo[3,2-d]pyrimidines.

InChI:InChI=1/C9H9NO3/c1-12-7-3-4-8(10-6-11)9(5-7)13-2/h3-5H,1-2H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 2735-04-8 2,4-Dimethoxyaniline 
• 90349-41-0 2,4-dimethoxybenzoyl azide 
• 77152-08-0 trifluoromethylcopper(I) 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 1984-21-0 1-isocyano-2,4-dimethoxybenzene 
• 103956-10-1 2,4-dimethoxybenzohydrazide 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 

Downstream Products

• 23122-15-8 (2,4-Dimethoxy-phenyl)-carbamic acid 3-methoxycarbonylamino-phenyl ester 
• 92551-51-4 1-(p-Chlor-phenyl)-3-(2,4-dimethoxy-phenyl)-harnstoff 
• 22546-38-9 C₁₀H₁₅N₃O₃ 
• 120958-85-2 1-(2,4-Dimethoxy-phenyl)-3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-urea 
• 59741-06-9 (2,4-Dimethoxy-phenyl)-carbamic acid quinolin-8-yl ester 
• 862251-07-8 (R)-3-(2,4-Dimethoxy-phenyl)-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 919120-06-2 C₂₈H₄₀N₄O₄ 
• 919120-05-1 C₂₈H₄₀N₄O₄ 
• 1119859-76-5 3-amino-N-(2,4-dimethoxyphenyl)-1H-indazole-1-carboxamide 

Relevant articles and documents

Copper-catalyzed N[sbnd]H/S[sbnd]H functionalization: A strategy for the synthesis of benzothiadiazine derivatives

A copper-mediated N[sbnd]S bond-forming reaction via N[sbnd]H/S[sbnd]H activation is described. This reaction occurs under mild conditions with high efficiency, step economy, and tolerates a wide variety of functional groups, providing an efficient means of accessing biologically important 1,2,4-benzothiadiazin-3(4H)-ones.

One-pot and novel route for the synthesis of 4-substituted-1,2,4- triazolidine-3,5-diones

The efficient and one-pot synthesis of 4-substituted-1,2,4-triazolidin-3,5- dione derivatives (4-substituted urazoles) via combination of triphosgene, substituted anilines, and ethyl carbazate in the presence of cesium carbonate is presented.

Rapid construction of isatin derivatives via addition of bis(alkylthio)carbenes to aryl isocyanates

Thermally induced cyclization between bis(alkylthio)carbenes, derived from the corresponding oxadiazolines, and substituted aryl isocyanates provides access to a variety of isatin derivatives with good efficiency.