84422-52-6Relevant academic research and scientific papers
A facile synthesis of spiroisoxazolines: Intramolecular cyclization of 3-aryl-2-nitroacrylates promoted by titanium tetrachloride
Hirotani, Seiko,Kaji, Eisuke
, p. 4255 - 4270 (1999)
Titanium tetrachloride-induced cyclization of 3-(o- or m-substituted p- methoxyphenyl)-2-nitro acrylates (1) provided stereoselectively (4α,5β)-1- oxa-2-azaspiro[4, 5]deca-2,6,9-trien-8-ones (2). Ortho-substituted p- methoxyphenyl nitroacrylates gave 2 in good yield. 3-(4'-methoxy-1'- naphthyl)-2-nitroacrylate also reacted with titanium tetrachloride to give quantitatively (4α,5β)-4'-oxospiro[isoxazole(4H)5,1'(4'H)-naphthatene]. 3- (10'-methoxy-9'-anthryl)-2-nitroacrylate was converted to 10- oxospiro[anthracene-(10H)9,5'(4'H)-isoxazole].
Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group
Chen, Xiao-Yang,Ozturk, Seyma,Sorensen, Erik J.
supporting information, p. 6280 - 6283 (2017/12/08)
The direct Pd-catalyzed ortho C-H hydroxylation of benzaldehydes was achieved using 4-chloroanthranilic acid as the transient directing group, 1-fluoro-2,4,6-trimethylpyridnium triflate as the bystanding oxidant, and p-toluenesulfonic acid as the putative oxygen nucleophile. The unusual C-H chlorination and polyfluoroalkoxylation reactions signaled the importance of external nucleophiles to the outcome of Pd(IV) reductive eliminations.
Total synthesis of (±) mutisianthol and (±) epi-mutisianthol via intramolecular oxidative Heck cyclization approach Dedicated to the late Professor M. G. Kulkarni, Department of Chemistry, SPPU, Pune for his pioneering work in the field of Wittig olefinat
Bhorkade, Shashikant B.,Gavhane, Kishor B.,Shinde, Vaishali S.
, p. 1954 - 1959 (2016/04/05)
A simple and straight forward synthesis of (±) mutisianthol and its epimer is described. Implementation of 4-pentenal derivative for palladium catalyzed intramolecular 5-endo-trig Heck cyclization is effective. Other key steps involved are Wittig olefinat
BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES
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Page/Page column 27, (2009/02/11)
The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
An Improved Synthesis of Naturally Occuring Coumarins: Synthesis of Herniarin, Scoparone and 7-Methoxy-6-methylcoumarin
Mali, R. S.,Yadav, V. J.,Zaware, R. N.
, p. 759 - 760 (2007/10/02)
Vilsmeier-Haack reaction of methoxybenzenes (1a-c) gives aldehydes (2a-c), which on demethylation with AlCl3 in CH2Cl2 yield the hydroxyaldehydes (3a-c).These hydroxyaldehydes on reaction with carbethoxymethylenetriphenylphosphorane furnish the naturally occuring coumarins, herniarin (4a), scoparone (4b) and 7-methoxy-6-methylcoumarin (4c).
