84424-70-4

Basic information

• Product Name: ethyl 2-hydroxy-4-oxo-4-(4-pentoxyphenyl)-2-butenoate
• Synonyms: ethyl 2-hydroxy-4-oxo-4-(4-pentoxyphenyl)-2-butenoate
• CAS NO: 84424-70-4
• Molecular Weight: 306.359
• Mol File: 84424-70-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-hydroxy-4-oxo-4-(4-pentoxyphenyl)-2-butenoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-hydroxy-4-oxo-4-(4-pentoxyphenyl)-2-butenoate(84424-70-4)
• EPA Substance Registry System: ethyl 2-hydroxy-4-oxo-4-(4-pentoxyphenyl)-2-butenoate(84424-70-4)

Safety Data

• Hazardous Substances Data: 84424-70-4(Hazardous Substances Data)

Upstream product

• 5467-56-1 4-pentyloxyacetophenone 
• 95-92-1 oxalic acid diethyl ester 
• 110-53-2 1-Bromopentane 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 1450606-86-6 5-(4-pentyloxyphenyl)isoxazole-3-carboxylic acid 
• 1450606-79-7 ethyl 5-(4-(pentyloxy)phenyl)isoxazole-3-carboxylate 
• 1450606-99-1 N-(1-adamantyl)-5-(4-pentyloxyphenyl)isoxazole-3-carboxamide 

Relevant articles and documents

3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis

Recent investigations showed that anandamide, the main endogenous ligand of CB1 and CB2 cannabinoid receptors, possesses analgesic, antidepressant and anti-inflammatory effects. In the perspective to treat inflammatory bowel disease (IBD), our approach was to develop new selective CB2 receptor agonists without psychotropic side effects associated to CB1 receptors. In this purpose, a new series of 3-carboxamido-5- aryl-isoxazoles, never described previously as CB2 receptor agonists, was designed, synthesized and evaluated for their biological activity. The pharmacological results have identified great selective CB2 agonists with in vivo anti-inflammatory activity in a DSS-induced acute colitis mouse model.