1450606-99-1

Basic information

• Product Name: N-(1-adamantyl)-5-(4-pentyloxyphenyl)isoxazole-3-carboxamide
• Synonyms: N-(1-adamantyl)-5-(4-pentyloxyphenyl)isoxazole-3-carboxamide
• CAS NO: 1450606-99-1
• Molecular Weight: 408.541
• Mol File: 1450606-99-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(1-adamantyl)-5-(4-pentyloxyphenyl)isoxazole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-adamantyl)-5-(4-pentyloxyphenyl)isoxazole-3-carboxamide(1450606-99-1)
• EPA Substance Registry System: N-(1-adamantyl)-5-(4-pentyloxyphenyl)isoxazole-3-carboxamide(1450606-99-1)

Safety Data

• Hazardous Substances Data: 1450606-99-1(Hazardous Substances Data)

Upstream product

• 79887-16-4 1-ethynyl-4-(pentyloxy)benzene 
• 84424-70-4 ethyl 2-hydroxy-4-oxo-4-(4-pentoxyphenyl)-2-butenoate 
• 5467-56-1 4-pentyloxyacetophenone 
• 768-94-5 1-Adamantanamine 
• 1450606-86-6 5-(4-pentyloxyphenyl)isoxazole-3-carboxylic acid 
• 110-53-2 1-Bromopentane 
• 99-93-4 4-Hydroxyacetophenone 

Relevant articles and documents

Oxidize Amines to Nitrile Oxides: One Type of Amine Oxidation and Its Application to Directly Construct Isoxazoles and Isoxazolines

A facile oxidative heterocyclization of commercially available amines and tert-butyl nitrite with alkynes or alkenes leading to isoxazoles or isoxazolines is described. The unprecedented strategy of the oxidation of an amine directly to a nitrile oxide was used in this cyclization process. This reaction is highly efficient, regiospecific, operationally simple, mild, and tolerant of a variety of functional groups. Control experiments support a nitrile oxide intermediate mechanism for this novel class of oxidative cyclization reactions. Moreover, synthetic applications toward bioactive molecular skeletons and the late-stage modification of drugs were realized.