84441-54-3Relevant articles and documents
Preparation method of (R)-1-(6-amino-9H-purine-9-yl)2-phenyl ester
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Paragraph 0020-0022, (2017/07/21)
The invention discloses a preparation method of preparation method of (R)-1-(6-amino-9H-purine-9-yl)2-phenyl ester, and belongs to the field of chemical synthesis. According to the preparation method, in a solvent, (chloromethyl) phosphonic acid phenyl ester is taken as an initial raw material, substitution reaction with sodium iodide is carried out, basic hydrolysis is carried out, and an obtained product is reacted with (S)-1-(6-amino-9H-purine-9-yl) propan-2-ol so as to obtain the reaction finished product (R)-1-(6-amino-9H-purine-9-yl)2-phenyl ester. The conditions are convenient to control; post-treatment is simple; few side reaction is caused; yield is high; and requirements of industrialized production are satisfied.