84446-03-7

Basic information

• Product Name: 4-Oxazoleacetic acid, 2-phenyl-, ethyl ester
• CAS NO: 84446-03-7
• Molecular Formula: C13H13NO3
• Molecular Weight: 231.251
• Mol File: 84446-03-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Oxazoleacetic acid, 2-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazoleacetic acid, 2-phenyl-, ethyl ester(84446-03-7)
• EPA Substance Registry System: 4-Oxazoleacetic acid, 2-phenyl-, ethyl ester(84446-03-7)

Safety Data

• Hazardous Substances Data: 84446-03-7(Hazardous Substances Data)

Upstream product

• 929-61-3 ethyl octyl ether 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 55-21-0 benzamide 
• 144-55-8 sodium hydrogencarbonate 
• 85322-13-0 Z-5-(Ethoxycarbonyl)methylene-5,6-dihydro-3-phenyl-4H-1,2,4-oxadiazine 

Downstream Products

• 22086-89-1 (2-phenyloxazol-4-yl)acetic acid 
• 173173-54-1 2-(2-phenyloxazol-4-yl)-ethanol 

Relevant articles and documents

Thiazolidinedione derivatives, their production and use

Thiazolidinedione derivatives of the general formula: STR1 [wherein R1 is hydrogen or a hydrocarbon residue or heterocyclic residue which may each be substituted; R2 is hydrogen or lower alkyl which may be substituted by hydroxyl group; X is an oxygen or sulfur atom; Z is a hydroxylated methylene or carbonyl; m is 0 or 1; n is an integer of 1 to 3; L and M represent independently a hydrogen atom or L and M combine with each other to cooperate jointly to form a linkage] and their salts, which are novel compounds, possess blood-glucose and blood-lipid lowering actions in mammals, and are of value as a therapeutic agent for diabetes and therapeutic agent for hyperlipemia.

RING-TRANSFORMATION OF 1,2,4-OXADIAZINE DERIVATIVES INTO 4-HYDROXYPYRIMIDINE DERIVATIVES: CATALYTIC HYDROGENATION OF 3-ARYL-5-ETHOXYCARBONYLMETHYLENE-5,6-DIHYDRO-4H-1,2,4-OXADIAZINE DERIVATIVES

Catalytic hydrogenation of 3-aryl-5-ethoxycarbonylmethylene-5,6-dihydro-4H-1,2,4-oxadiazine derivatives (1) is described.The method leads to new synthesis of 2-aryl-4-hydroxypyrimidine derivatives (3) involving cyclization of ethyl 3-benzimidoylimino-4-hydroxybutanoate derivatives (2) by the elimination of ethanol.Nickel catalyzed hydrogenation of 1 gave ethyl 2-aryl-4-oxazoylacetate (4) as a by-product besides product 3.