84449-80-9

Basic information

• Product Name: 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride
• Synonyms: 4-(2-Piperdinoethoxy)-benzoic acid Hydrochloride;4-[2-(1-Pipiridine)e;4-{2-(1-Piperidino)ethoxy}benzoic acid HCl;Benzoic acid,4-[2-(1-piperidinyl)ethoxy]-, hydrochloride (1:1);Raloxifene Benzoic Acid Impurity;4-[2-(1-piperridiyl)ethoxy] benzoic acid hydro chloride;4-(2-PIPERIDIN-1-YL-ETHOXY)-BENZOIC ACID HYDROCHLORIDE;4-(2-PIPERIDINOETHOXY)BENZOIC ACID HCL
• CAS NO: 84449-80-9
• Molecular Formula: C₁₄H₁₉NO₃*ClH
• Molecular Weight: 285.77
• EINECS: 282-882-9
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 84449-80-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 267-271°C dec.
• Boiling Point: 413.2 °C at 760 mmHg
• Flash Point: 203.7 °C
• Appearance: /
• Vapor Pressure: 4.9E-08mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride(84449-80-9)
• EPA Substance Registry System: 4-[2-(1-Pipiridine)ethoxybenzoic acid hydrochloride(84449-80-9)

Safety Data

• Hazardous Substances Data: 84449-80-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 84449-80-9 differently. You can refer to the following data:
1. An intermediate in the synthesis of Raloxifene hydrochloride.
2. An intermediate in the synthesis of Raloxifene hydrochloride

InChI:InChI=1/C13H17NO3.ClH/c15-13(16)11-3-5-12(6-4-11)17-10-9-14-7-1-2-8-14;/h3-6H,1-2,7-10H2,(H,15,16);1H

Upstream product

• 93148-78-8 ethyl 4-(2-Piperidinylethoxy)benzoate 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 408538-22-7 N-hydroxyethylpiperidine 
• 628-63-7 1-pentyl acetate 
• 1648-99-3 2,2,2-Trifluoroethanesulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 89407-97-6 4-[2-(N-piperidine)-ethoxy]benzoic acid methyl ester 

Downstream Products

• 82640-04-8 raloxifene hydrochloride 
• 933824-14-7 C₃₃H₃₂Cl₂N₂O₃ 
• 933824-15-8 C₃₃H₃₂N₄O₇ 
• 933824-16-9 C₃₅H₃₈N₂O₃ 
• 933824-13-6 C₃₃H₃₄N₂O₃ 
• 84449-84-3 6-benzenesulfonyloxy-2-(4-benzenesulfonyloxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo-[b]thiophene, hydrochloride 
• 84449-85-4 <6-<(methylsulfonyl)oxy>-2-<4-<(methylsulfonyl)oxy>phenyl>benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride 
• 84449-83-2 6-benzoyloxy-2-(4-benzoyloxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride 
• 165742-76-7 [2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone 
• 166975-76-4 4-(2-(piperidin-1-yl)ethoxy)benzoyl chloride 
• 84541-36-6 [2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride 
• 84449-90-1 Raloxifen 

Relevant articles and documents

SMALL MOLECULE ANTAGONISTS OF SUMO RELATED MODIFICATION OF CRMP2 AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperidinyl-benzoimidazole structure which function as antagonists of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2), and their use as therapeutics for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and/or pain (e.g., neuropathic pain).

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds

The 3,5-bis(arylidene)-4-piperidones 1 contain the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore which is considered to interact at a complementary binding site in susceptible neoplasms. The hypothesis was formulated that the presence of an acyl group attached to the piperidyl nitrogen atom in series 1 may interact with an additional binding site thereby enhancing cytotoxic potencies. This concept led to the synthesis of various N-acyl-3,5-bis(arylidene)-4-piperidones 3-7 many of which displayed significant cytotoxicity towards a variety of cancer cell lines. A comparison of the potencies between the compounds in series 1 and the related nonquaternary analogues 3-6 revealed that in approximately half of the comparisons made, the N-acyl analogues had increased potencies.

Process for preparing benzoic acids

An improved process for the preparation of 4[(2-piperidin-1-yl)ethoxy]benzoic acid derivatives, comprising reacting a haloalkyl amine of formula (III) with a compound of formula (IV) in the presence of a hydrated inorganic base in an appropriate solvent.