84449-85-4

Usage

Uses

Used in Pharmaceutical Industry:
Methanone, [6-[(methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride is used as a pharmaceutical compound for its potential therapeutic effects. Its unique structure and functional groups may contribute to its interaction with biological targets, making it a promising candidate for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, Methanone, [6-[(methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride serves as a subject of study for understanding its chemical properties, reactivity, and potential applications in various chemical processes.
Used in Material Science:
Methanone, [6-[(methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride may be utilized in material science for the development of new materials with unique properties. Its structural features and functional groups could be harnessed to create materials with specific characteristics for various applications.
Used in Environmental Applications:
The potential use of Methanone, [6-[(methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride in environmental applications could be explored, such as in the development of new methods for pollution control or environmental remediation, given its unique chemical composition.

Upstream product

• 166975-76-4 4-(2-(piperidin-1-yl)ethoxy)benzoyl chloride 
• 84449-65-0 6-<(methylsulfonyl)oxy>-2-<4-<(methylsulfonyl)oxy>phenyl>benzothiophene 
• 15570-12-4 3-methoxybenzenethiol 
• 84449-80-9 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 63675-73-0 α-(3-methoxyphenyl-thio)-4-methoxyacetophenone 
• 63676-22-2 6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene 
• 63675-74-1 2-(4'-methoxyphenyl)-6-methoxybenzothiophene 

Downstream Products

• 82640-04-8 raloxifene hydrochloride 
• 676635-74-8 [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-4-[2-(1-piperidinyl)ethoxy]phenyl L-lactate 
• 84449-90-1 Raloxifen 

Relevant academic research and scientific papers

PREPARATION OF RALOXIFENE AND ITS SALTS

The invention provides processes for the preparation of pure raloxifene or its salts, involving hydrolyzing 6-methylsulfonyloxy-2-[(4-methylsulfonyloxy)-phenyl]-3-[4(2-(piperidinyl)ethoxy)benzoyl]benzothiophene hydrochloride, using an aqueous base.

Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzothiophene Derivatives Leading to thien-3-yl>phenyl>methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with On...

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzothiophene derivatives was synthesized.These compounds were prepared by Friedel-Crafts aroylation of appropriate O-protected 2-arylbenzothiophene nuclei with basic side-chain-bearing benzoyl chlorides followed by removal of the protective groups to provide the desired compounds containing both hydroxyl and basic side-chain functionality.A particularly useful method for the cleavage of aryl methoxy ethers without removal of (dialkylamino)ethoxy side chain functionality elsewhere in the molecule was found to be AlCl3/EtSH.The benzothiophene derivatives were tested for their ability to inhibit the growth-stimulating action of estradiol on the immature rat uterus.Seemingly minor changes in the side-chain amine moiety were found to have profound effects on the ability of the compounds to antagonize estradiol.Analogues having basic side chains containing cyclic (pyrrolidine, piperidine, and hexamethyleneamine) moieties were found to have less intrinsic estrogenicity and to antagonize estradiol action more completely than their noncyclic counterparts.The most effective antiestrogen in the series, compound 44, thien-3-yl>phenyl>methanone, elicited a modest uterotropic activity that did not increase with increasing dose.In antagonism of estradiol, 44 exhibited a degree of inhibition surpassing that of tamoxifen at any dose tested.The new benzothiophene antiestrogen was also shown to have high affinity for rat uterine cycloplasmic estrogen receptor and to be an inhibitor of the growth of DMBA-induced rat mammary tumors.

Antiestrogenic and antiandrugenic benzothiophenes

6-Hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, its ethers and esters, and the physiologically acceptable acid addition salts thereof, are valuable antiestrogens and antiendrogens.

Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes

The use of particularly advantageous protecting groups for the hydroxy groups of 6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophenes provides a high-yielding process for the preparation of such compounds having a 4-(2-aminoethoxy)benzoyl 3-group.