84452-98-2

Usage

Reagent in organic synthesis

2,2-difluoroacetohydrazide is commonly used as a reagent in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. This means it is a key starting material or intermediate in the synthesis of various organic compounds.

Reaction with various functional groups

2,2-difluoroacetohydrazide is known for its ability to react with a wide range of functional groups, making it a versatile building block for the creation of new molecules. This property allows it to be used in diverse chemical reactions and synthesis processes.

Potential applications in materials science

2,2-difluoroacetohydrazide has potential applications in the field of materials science, particularly in the development of new polymers and composite materials. This suggests that it may be used to create advanced materials with specific properties for various applications.

Hazards and proper handling

Despite its utility, 2,2-difluoroacetohydrazide should be handled with care, as it may pose hazards if not used properly. This means that appropriate safety precautions and procedures should be followed when working with 2,2-difluoroacetohydrazide to minimize the risk of accidents or exposure to harmful substances.

Upstream product

• 433-53-4 difluoroacetic acid methyl ester 
• 454-31-9 ethyl difluoroacetate 

Downstream Products

• 1383747-46-3 4-Benzyl-3-difluoromethyl-5-methyl-4H-1,2,4-triazole 
• 1313441-55-2 7-bromo-1-(difluoromethyl)-8-phenyl-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazine 

Relevant academic research and scientific papers

SSAO INHIBITOR

The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.

Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration

The oxytocin receptor (OTR) plays a major role in the control of male sexual responses. Antagonists of the OTR have been reported to inhibit ejaculation in animal models and serve as a potential treatment for premature ejaculation (PE). Herein, we describe a novel scaffold featuring an aryl substituted 3-azabicyclo [3.1.0] hexane structure. The lead compound, SHR1653, was shown to be a highly potent OTR antagonist, which exhibited excellent selectivity over V1AR, V1BR, and V2R. This novel molecule was shown to have a favorable pharmacokinetic profile across species, as well as robust in vivo efficacy in a rat uterine contraction model. Interestingly, SHR1653 exhibited excellent blood-brain barrier penetration, which might be beneficial for the treatment of CNS-related PE.

Efficient synthesis of tri- and difluoroacetyl hydrazides as useful building blocks for non-symmetrically substituted, fluoroalkylated 1,3,4-oxadiazoles

[Figure not available: see fulltext.] A convenient and efficient approach to 2-arylamino-5-fluoroalkyl-1,3,4-oxadiazoles has been established via heterocyclization of tri- and difluoroacetylated thiosemicarbazides using dicyclohexylcarbodiimide. A heteroc

Process for the production of pyrazoles

The present invention relates to novel processes for the production of compounds of formula I

Chemical compounds

Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).