84454-97-7Relevant academic research and scientific papers
N-Nicotinoyl dopamine inhibits skin pigmentation by suppressing of melanosome transfer
Kim, Bora,Hwang, Jae Sung,Kim, Hyun-Soo
, p. 250 - 256 (2015)
We investigated the inhibitory effects of a niacinamide derivative, N-Nicotinoyl dopamine (NND) on melanogenesis. NND inhibits melanosome transfer in a normal human melanocyte-keratinocyte co-culture system and through phagocytic ability without affecting viability of cells while it did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. In addition, safety of NND was verified through performing neural stem cell morphology assay. Our findings indicate that NND may potentially be used for cosmetic industry for improvement of skin whitening and therapies related with several skin disorders, and the effect of NND may be acquired via reduction of melanosome transfer.
Synthesis of nicotinamide derivatives having a hydroxy-substituted benzene ring and the influence of their structures on the apoptosis-inducing activity against leukemia cells
Yamaguchi, Tomoko,Matsumura, Yuriko,Ishii, Takuya,Tokuoka, Yoshikazu,Kurita, Keisuke
experimental part, p. 289 - 297 (2012/03/27)
With the view of developing novel apoptosis-inducing agents against malignant cells, nicotinamide derivatives containing substituted O-benzoyl-tyrosine, dopamine, and norepinephrine residues were synthesized. Antiproliferative activity measurements using leukemia U937 cells revealed that the benzoyl-tyrosine derivative having two hydroxys at C-2 and C-3 on the benzoyl group, and the one having a hydroxy at C-2 and a methoxy at C-4 proved the most potent among the 9 nicotinamide derivatives. The IC50 values of these compounds were 0.87 and 3.15 μM, which indicates their noteworthy activity compared with epigallocatechin gallate, a catechin component in green tea known for its noticeable activity. The cell death process was confirmed to be the result of apoptosis by agarose gel electrophoresis and dye staining, suggesting the high potential of these compounds as apoptosis-inducing anticancer agents. Drug Dev Res 72: 289-297, 2011.
Improved Delivery through Biological Membranes. 13. Brain-Specific Delivery of Dopamine with a Dihydropyridine Pyridinium Salt Type Redox Delivery System
Bodor, Nicholas,Farag, Hassan H.
, p. 528 - 534 (2007/10/02)
The dihydropyridine pyridinium salt type redox delivery system was used for the brain-specific delivery of dopamine.In vivo administration of the catechol-protected dopamine coupled with 1,4-dihydrotrigonelline as the carrier resulted in brain-specifi
