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Usage

Uses

Used in Pharmaceutical Industry:
5-Hydroxymethyl-3-(4-iodophenyl)-2-oxazolidinone is used as a reactant in the synthesis of 5-(aminomethyl)oxazolidine derivatives. These derivatives have been found to exhibit inhibitory effects on the monoamine oxidase type B enzyme in rats. Monoamine oxidase type B is an enzyme that is involved in the breakdown of neurotransmitters such as dopamine, norepinephrine, and serotonin. Inhibition of this enzyme can lead to increased levels of these neurotransmitters in the brain, which may have potential therapeutic benefits in the treatment of various neurological and psychiatric disorders.
In the synthesis process, 5-hydroxymethyl-3-(4-iodophenyl)-2-oxazolidinone reacts with appropriate amines to form the desired 5-(aminomethyl)oxazolidine derivatives. These derivatives can then be further studied and optimized for their inhibitory activity against monoamine oxidase type B enzyme, leading to the development of new pharmaceutical agents with potential applications in the treatment of neurological and psychiatric disorders.
Furthermore, the unique structure of 5-hydroxymethyl-3-(4-iodophenyl)-2-oxazolidinone and its derivatives may also offer opportunities for exploration in other areas of pharmaceutical research, such as the development of new antibiotics, anti-inflammatory agents, or other therapeutic compounds. The versatility of 5-HYDROXYMETHYL-3-(4-IODOPHENYL)-2-OXAZOLIDINONE and its potential applications make it an important player in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C10H10INO3/c11-7-1-3-8(4-2-7)12-5-9(6-13)15-10(12)14/h1-4,9,13H,5-6H2

Upstream product

• 124-38-9 carbon dioxide 
• 540-37-4 p-aminoiodobenzene 
• 105-58-8 Diethyl carbonate 
• 4643-46-3 1-chloro-3-[(4-iodophenyl)amino]propan-2-ol 

Relevant academic research and scientific papers

Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

Exploration of the structure–activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents

To gain further knowledge of the structure–activity relationship and druggability of novel oxazolidinone-based UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitors as Gram-negative antibacterial agents, compounds containing the hydrophobic tails

Stereocontrolled, Divergent, Al(lll)-Catalyzed Coupling of Chiral N-Aryl Epoxy Amines and CO2

A divergent coupling reaction was achieved between N-aryl epoxy amines and CO2. By using two different cocatalysts, tetrabutylammonium iodide (TBAI) or 4-dimethylaminopyridine (DMAP) together with an Al(III) Lewis acid, cyclic carbonates or oxazolidinones were selectively produced through two distinct reaction pathways, respectively. The proposed reaction mechanism was supported by the stereochemical determination of the products. A gram-scale production of Linezolid was successfully achieved.

Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is —O— or —S—; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2 R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): wherein Rc is, for example, R13CO—, R13SO2— or R13CS—; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.