844694-85-5

Usage

Chemical Properties

White to Off-White Solid

InChI:InChI=1/C31H36NO3.BrH/c1-34-29-19-26-18-27(31(33)28(26)20-30(29)35-2)17-23-13-15-32(16-14-23,21-24-9-5-3-6-10-24)22-25-11-7-4-8-12-25;/h3-12,19-20,23,27H,13-18,21-22H2,1-2H3;1H/q+1;/p-1

Upstream product

• 100-39-0 benzyl bromide 
• 120014-30-4 debenzyldonepezil 
• 872-85-5 pyridine-4-carbaldehyde 
• 2107-69-9 5,6-dimethoxy-1-indanone 
• 877606-65-0 (E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one 
• 120014-06-4 donepezil 
• 142057-77-0 donepezil hydrochloride 

Relevant academic research and scientific papers

Donepezil hydrochloride impurities and preparation method thereof

The present invention relates to a new impurity of donepezil hydrochloride as shown below and a method for preparing it, said method comprising reacting donepezil and benzyl chloride or bromide to form a quaternary ammonium salt, and then reactivated by rearrangement to obtain a target compound. Impurities obtained by the present invention are very useful for studying the source of impurities and the development of new analytical methods.

CRYSTALLINE FORM OF DONEPEZIL HYDROCHLORIDE

A process for preparing crystalline form I of donepezil hydrochloride comprises: a) condensing 5,6-dimethoxy-2-piperidin-4-yl-methyl-indan-1-one with benzyl bromide and reacting a condensation product with hydrobromic acid to form donepezil hydrobromide; and b) hydrolyzing donepezil hydrobromide, followed by reacting with aqueous hydrochloric acid.

New synthesis of donepezil through palladium-catalyzed hydrogenation approach

A new, economical, and efficient process has been developed for large-scale synthesis of donepezil 1, an anti-Alzheimer's drug. The process involves palladium-catalyzed hydrogenation of (2E)-5,6-dimethoxy-2-(pyridin-4- ylmethylene)indan-1-one 6 to provide 5,6-dimethoxy-2-(piperidin-4-ylmethyl) indan-1-one 8 as a key step. Copyright Taylor & Francis LLC.