844864-99-9Relevant academic research and scientific papers
Synthesis of stereohomogeneous cyclopropanecarbaldehydes and cyclopropyl ketones by cycloalkylation of 4-hydroxy-1-alkenyl carbamates
Kalkofen, Rainer,Brandau, Sven,Wibbeling, Birgit,Hoppe, Dieter
, p. 6667 - 6669 (2004)
Small rings: Only a few methods are known for the synthesis of cyclopropane carbaldehydes and cyclopropyl ketones 2. In a new, simple route to highly enantioenriched trisubstituted three-membered rings, 4-hydroxy-1-alkenyl N,N-di-isopropyl carbamates 1 are treated with NaH, resulting in migration of the carbamoyl group and intramolecular enolate alkylation.
Enantio- and diastereoselective synthesis of highly substituted acylcyclopropanes from homoaldol products by stereospecific homoallylic cyclization
Kalkofen, Rainer,Brandau, Sven,Uenaldi, Seda,Frohlich, Roland,Hoppe, Dieter
, p. 4571 - 4580 (2007/10/03)
Highly enantioenriched 4-hydroxy-1-alkenyl N,N-diisopropylcarbamates, easily available by asymmetric homoaldol reaction, cyclize by treatment with sodium hydride to form (1r,2t,3t)-configured 1-acylcyclopropanes with high diastereoselectivity. The decisiv
Enantioselective synthesis of cyclopropanes by aldehyde homologation
Risatti, Christina A.,Taylor, Richard E.
, p. 6671 - 6672 (2007/10/03)
An efficient method for the enantioselective preparation of structurally diverse cyclopropanes has been developed. Sequential homoaldol coupling and activation steps result in a three-carbon homologation of an aldehyde to give a nonracemic, stereochemical
