84487-03-6

Basic information

• Product Name: 2-Chloro-3-nitropyridine-6-amine
• Synonyms: 2-Chloro-3-nitropyridine-6-amine;6-Amino-2-chloro-3-nitropyridine;6-Chloro-5-nitropyridin-2-aMine;6-Chloro-5-nitro-pyridin-2-ylaMine
• CAS NO: 84487-03-6
• Molecular Formula: C₅H₄ClN₃O₂
• Molecular Weight: 173.5572
• Mol File: 84487-03-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 188 °C
• Boiling Point: 393.6°Cat760mmHg
• Flash Point: 191.9°C
• Appearance: /
• Density: 1.596g/cm³
• Vapor Pressure: 2.1E-06mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -1.22±0.37(Predicted)
• CAS DataBase Reference: 2-Chloro-3-nitropyridine-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-nitropyridine-6-amine(84487-03-6)
• EPA Substance Registry System: 2-Chloro-3-nitropyridine-6-amine(84487-03-6)

Safety Data

• Hazardous Substances Data: 84487-03-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-nitropyridine-6-amine is a chemical compound with the molecular formula C5H4ClN3O2. It is a derivative of pyridine, and its structure consists of a pyridine ring with a chlorine atom at the 2-position and a nitro group at the 3-position, and an amine group at the 6-position. 2-Chloro-3-nitropyridine-6-amine is used in the synthesis of pharmaceuticals and agricultural chemicals. It can also be used as a building block in organic synthesis for the preparation of various heterocyclic compounds. 2-Chloro-3-nitropyridine-6-amine is a yellow crystalline solid and is considered to be a hazardous chemical, and proper safety measures should be taken when handling it.

InChI:InChI=1/C5H4ClN3O2/c6-5-3(9(10)11)1-2-4(7)8-5/h1-2H,(H2,7,8)

Upstream product

• 45644-21-1 6-chloropyridin-2-amine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 92741-41-8 6-amino-2-ethylthio-3-nitropyridine 

Relevant articles and documents

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

HETEROARYLSULFONYL-SUBSTITUTED PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER

There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3 and X have meanings provided in the description, which compounds are useful in the treatment of cancers.

Regioselectivity of the Amination of Some 3-Nitropyridines by Liquid Ammonia / Potassium Permanganate

3-Nitropyridine and some of its derivatives are aminated in a liquid ammonia solution of potassium permanganate to the corresponding 2- and (or) 4- and (or) 6-amino compounds.Quantumchemical calculations for a few 3-nitropyridines suggest that the experimentally observed regioselectivity of the amination is controlled by Coulombic interaction. --- Key Words: Amination / Nitropyridines / Reactivity indices / Calculations, MNDO