84487-03-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-3-nitropyridine-6-amine serves as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications. Its unique structure allows for the creation of diverse chemical entities that can target specific biological pathways.
Used in Agricultural Chemical Production:
2-Chloro-3-nitropyridine-6-amine is also utilized in the production of agricultural chemicals, playing a crucial role in the development of pesticides and other agrochemicals that enhance crop protection and yield.
Used as a Building Block in Organic Synthesis:
2-Chloro-3-nitropyridine-6-amine is employed as a versatile building block in organic synthesis for the preparation of various heterocyclic compounds. Its reactivity and functional groups enable the formation of complex molecular structures with potential applications in different industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C5H4ClN3O2/c6-5-3(9(10)11)1-2-4(7)8-5/h1-2H,(H2,7,8)

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 45644-21-1 6-chloropyridin-2-amine 

Downstream Products

• 92741-41-8 6-amino-2-ethylthio-3-nitropyridine 

Relevant academic research and scientific papers

EP300/CREBBP INHIBITOR

The present invention provides a compound having excellent histone acetyltransferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

HYDROCARBYLSULFONYL-SUBSTITUTED PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER

There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3 and X have meanings provided in the description, which compounds are useful in the treatment of cancers.

HETEROARYLSULFONYL-SUBSTITUTED PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER

There is provided compounds of formula I (I) or pharmaceutically-acceptable salts thereof, wherein L, R1, R2, R3 and X have meanings provided in the description, which compounds are useful in the treatment of cancers.

Zinc-promoted direct amination of nitropyridines with methoxyamine via vicarious nucleophilic substitution

Direct animation of nitropyridines with methoxyamine in the presence of a stoichiometric amount of zinc(II) chloride under basic conditions proceeds to give aminonitropyridines.

Regioselectivity of the Amination of Some 3-Nitropyridines by Liquid Ammonia / Potassium Permanganate

3-Nitropyridine and some of its derivatives are aminated in a liquid ammonia solution of potassium permanganate to the corresponding 2- and (or) 4- and (or) 6-amino compounds.Quantumchemical calculations for a few 3-nitropyridines suggest that the experimentally observed regioselectivity of the amination is controlled by Coulombic interaction. --- Key Words: Amination / Nitropyridines / Reactivity indices / Calculations, MNDO