84499-61-6

Usage

Derivative of

Purine base (key component of DNA and RNA)

Common uses

Pharmaceutical precursor, building block for organic synthesis

Chemical structure

Amino group, ketone group, purine ring

Potential applications

Wide range in pharmaceutical and chemical industries

Safety precautions

Handle with care and follow safety guidelines, as it can be hazardous if not properly handled.

Upstream product

• 59277-89-3 acycloguanosine 
• 30426-58-5 2-azidoacetyl chloride 
• 84499-68-3 9-<<2-(azidoacetoxy)ethoxy>methyl>guanine 

Relevant academic research and scientific papers

Derivatives of 9-(2-hydroxyethoxymethyl) guanine

Compounds of the general formula STR1 (wherein X represents an oxygen or sulphur atom, R1 represents a hydroxy or amino group, R2 represents a hydrogen atom or a group of formula --CH2 OR3a and R3 and R3a which may be the same or different, each represents an amino acid acyl radical) and physiologically acceptable salts thereof are useful for the treatment of viral infections and have been found to have a surprisingly high water-solubility which renders them of value in the formulation of aqueous pharmaceutical preparations. Processes for preparing the compounds are described.

Synthesis and Antiviral Activity of Water-Soluble Esters of Acyclovir guanine>

Several water-soluble ester derivatives of acyclovir guanine>, i.e., the 2'-O-glycyl-, 2'-O-α-alanyl, 2'-O-β-alanyl- and 2'-O-3-carboxypropionyl esters, were synthesized and evaluated for their antiviral activity in cell cultur