84533-99-3Relevant academic research and scientific papers
Amidrazones. 14. The Formation of 1,1-Disubstituted Hydrazines from the Base-promoted Hydrolysis of 1,1-Disubstituted-3-amino-4,5-dihydro-1H-pyrazolium Halides: Mechanistic Considerations
Smith, Richard F.,Dennis, Lisa A.,Ryan, William J.,Rodriguez, George,Brophy, Keith A.
, p. 181 - 183 (2007/10/02)
Three mechanistic pathways are considered for the hydroxide-promoted conversion of 1,1-disubstituted-3-amino-4,5-dihydro-1H-pyrazolium halides 1 to 1,1-disubstituted hydrazines, ammonia and sodium 3-hydroxypropanoate.Evidence presented in this paper supports a hydrolysis mechanism c that is initiated by hydroxide ion addition to the 3-position of 1 to form a tetrahedral intermediate 7.
Therapeutically active 3-amino-1-phenyl(and substituted phenyl)-2-pyrazolines
-
, (2008/06/13)
This disclosure describes certain 3-amino-1-phenyl-2-pyrazolines and 3-amino-1-substituted phenyl-2-pyrazolines and their C4 and C5 analogs useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.
