84547-64-8

Usage

Uses

Used in Organic Synthesis:
3-(Chloromethyl)-1-methyl-1H-pyrazole is used as a building block in organic synthesis for the preparation of various heterocyclic compounds. Its unique structure allows for the creation of a wide range of chemical entities with potential applications in different industries.
Used in Pharmaceutical Drug Production:
3-(Chloromethyl)-1-methyl-1H-pyrazole is utilized in the production of pharmaceutical drugs. Its presence in the molecular structure can contribute to the development of new medications with specific therapeutic properties.
Used in Agrochemicals:
3-(Chloromethyl)-1-methyl-1H-pyrazole is also employed in the agrochemical industry. Its incorporation into various formulations can lead to the development of effective products for agricultural use, such as pesticides or herbicides.
Safety Precautions:
It is important to handle 3-(Chloromethyl)-1-methyl-1H-pyrazole with caution, as it is considered a potential irritant and can be harmful if ingested or inhaled. Proper safety measures should be taken during its use to minimize any risks associated with exposure to 3-(Chloromethyl)-1-methyl-1H-pyrazole.

InChI:InChI=1/C5H7ClN2/c1-8-3-2-5(4-6)7-8/h2-3H,4H2,1H3

Upstream product

• 84547-62-6 (1-methyl-1H-pyrazol-3-yl)methanol 
• 17827-61-1 methyl ester of 1-methylpyrazole-3-carboxylic acid 
• 15787-79-8 chloromethyl β-chlorovinyl ketone 
• 57-14-7 N,N-Dimethylhydrazine 

Downstream Products

• 1607023-04-0 5-(4-chloro-3-methoxyphenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-49-3 5-(4-chloro-3-(2,2,2-trifluoroethoxy)phenyl)-3-(1-methyl-1H-pyrazol-3-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 

Relevant academic research and scientific papers

5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER

The invention is directed to substituted 5-(1H-benzo[d]imidazo-2-yl)- pyridin-2-amine and 5-(3H-imidazo[4,5-b]pyridin-6-yl)-pyridin-2-amine derivatives. Specifically, the invention is directed to compounds according to Formula (lb) wherein R', R2', R3', R4', Rs', R6', R7', and X1' are as defined herein; or a salt thereof including a pharmaceutically acceptable salt thereof. The compounds of the invention decrease MYC protein (c-MYC) in cells and/or inhibit p300/CBP histone acetyltransferase and can be useful in the treatment of cardiac hypertrophy, diabetes, obesity and nonalcoholic fatty liver disease, HIV, polycystic kidney disease, inflammatory diseases, ankylosing spondylitis, psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, cancer and pre-cancerous syndromes, and diseases associated with dysregulation of Myc or inhibition of p300/CBP histone acetyltransferase. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention still further discloses methods of reducing MYC protein (c-MYC) in cells and inhibiting p300/CBP histone acetyltransferase activity, and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS

The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.

1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines

Regioselective heterocyclization of alkyl 2-chloro-and 2,2-dichlorovinyl ketones with 1,1-dialkyl-hydrazines to 1,3-dialkyl-1H-pyrazoles and 1,3-dialkyl-5-chloro-1H-pyrazoles involves intermediate formation of the corresponding dialkylhydrazones. Fragment

New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-(5-halo)pyrazoles from chloro(bromo) vinyl ketones and N,N-dimethylhydrazine

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro-(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl(5-halo)pyrazoles. The reaction is accompanied by elimination of methyl halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.