84552-63-6

Usage

Uses

Used in Pharmaceutical Industry:
L-Proline, 1-L-tyrosyl-, 1,1-dimethylethyl ester is used as a building block for the synthesis of peptides and proteins, which are essential components of many pharmaceuticals. Its stability and protection for amino acid residues make it a valuable reagent in the development of new drugs and chemical compounds.
Used in Research and Development:
L-Proline, 1-L-tyrosyl-, 1,1-dimethylethyl ester is used as a reagent in the research and development of new drugs and chemical compounds. Its potential role in promoting antioxidant activity and protecting cells from oxidative stress makes it a promising candidate for further investigation and application in various fields.

Upstream product

• 16881-39-3 (S)-2-tert-butyl-1-benzylpyrrolidine-1,2-dicarboxylate 
• 2812-46-6 proline tert-butyl ester 
• 1164-16-5 Z-L-Tyr-OH 
• 84552-62-5 Z-Tyr-Pro-OBu^t 

Downstream Products

• 84552-67-0 Z-Ile-Tyr-Pro-Arg(Pme)-Gly-OBu^t 
• 84552-65-8 Z-Ile-Tyr-Pro-OH 
• 84552-64-7 Z-Ile-Tyr-Pro-OBu^t 

Relevant academic research and scientific papers

4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr): a New Amino and Imidazole Protecting Group in Peptide Synthesis

The 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group was introduced as a protecting group for the amino function, especially the ε-amino function of lysine, and the imidazole ring of histidine.The Nε-Mtr group was removable by dilute methanesulfonic acid-containing trifluoroacetic acid-thioanisole, but was stable to trifluoroacetic acid or catalytic hydrogenation.The Nim-Mtr group was removable by trifluoroacetic acid-dimethylsulfide or 1-hydroxybenzotriazole, but was more stable than the Nim-Tos or the Nim-Mbs group with triethylamine.To examine the usefulness of the Mtr group as a protecting group for use in peptide synthesis, mastoparan X and chicken gastrin releasing peptide (c-GRP) were synthesized, and this group was found to be very convenient for general solution synthesis.In particular, the introduction of Lys(Mtr) made possible a new strategy in peptide synthesis.Keywords-4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr); Nε-4-methoxy-2,3,6-trimethylbenzenesulfonyllysine; Nim-4-methoxy-2,3,6-trimethylbenzenesulfonylhistidine; methanesulfonic acid-trifluoroacetic acid-thioanisole deprotection; trifluoroacetic acid-dimethylsulfide deprotection; mastoparan X; chicken gastrin releasing peptide