845714-30-9Relevant articles and documents
Having optical activity cyclohexyl oxazoline ligand and its use
-
Paragraph 0252-0254, (2018/10/19)
The invention provides a synthetic method and application of a naphthenic oxazoline ligand with optical activity, particularly a novel oxazoline ligand of which the structure is as shown in the formula (I), and the definitions of all groups are stated in the description. The ligand can produce metal complexes together with the third to the thirteenth metal salts, is used for catalyzing asymmetrical organic synthetic reaction, and has the characteristics of high catalytic activity and high product enantioselectivity.
Asymmetric palladium-catalyzed hydroarylation of styrenes and dienes
Podhajsky, Susanne M.,Iwai, Yasumasa,Cook-Sneathen, Amanda,Sigman, Matthew S.
supporting information; experimental part, p. 4435 - 4441 (2011/08/06)
Alkenes are desirable and highly versatile starting materials for organic transformations, and well-known substrates for palladium catalysis. Typically, these reactions result in the formation of a new alkene product via β-hydride elimination. In contrast to this scenario, our laboratory has been involved in the development of alkene hydro- and difunctionalization reactions, where β-hydride elimination can be controlled. We report herein the development of an asymmetric palladium-catalyzed hydroarylation, which yields diarylmethine products in up to 75% ee. Interestingly, a linear free energy relationship is observed between the steric bulk of the ligand within a certain range and the ee of the reaction.
