845777-72-2

Upstream product

• 6783-05-7 trans-2-phenylvinylboronic acid 
• 95474-53-6 5-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-3-methyl-2-methylsulfanyl-3,5-dihydro-imidazol-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 19508-20-4 4-(4-methoxy-benzylidene)-2-styryl-4H-oxazol-5-one 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Mild, Efficient, One-Pot Synthesis of Imidazolones Promoted by N,O-Bistrimethylsilylacetamide (BSA)

The formation of imidazolones by means of dehydrative cyclization was developed, using bistrimethylsilylacetamide. This highly versatile, friendly, safe, and cost-effective reagent exhibited a very large scope of starting materials, since it can promote the formation of 4-benzylidene imidazolones, 4,4-dialkyl-imidazolones, bearing alkyl, aryl, or even no substituent at C2, the latter being unavailable by classical methods. This reagent also afforded clean and high-yielding one-pot reactions in the presence of amine or imine reagents.

An expeditious synthesis of 2,4-disubstituted 2-imidazolin-5-ones

2-Thiomethylimidazolin-5-one undergoes efficient palladium-catalyzed cross-coupling with boronic acids and organostannanes mediated by copper(I) thiophene-2-carboxylate.