84586-36-7Relevant academic research and scientific papers
Studies on Pyrimidine Derivatives. XXXVI. Reaction of 6-Substituted 2,4-Dimethylpyrimidines with Benzaldehyde in the Presence of Zinc Chloride
Sakamoto, Takao,Yoshizawa, Hiroshi,Yamanaka, Hiroshi
, p. 2005 - 2010 (2007/10/02)
The condensation of 2,4(2,6)-dimethylpyrimidines (7a-c), but not 6-methoxy-2,4-dimethylpyrimidine (7d), with benzaldehyde in the presence of zinc chloride occurred at the 4(6)-methyl group predominantly.In contrast, the reaction of 7d under the same condi
Studies on Pyrimidine Derivatives. XXX. The Palladium-Catalyzed Cross-Coupling Reaction of Iodopyrimidines with Terminal Olefinic Compounds
Sakamoto, Takao,Arakida, Hiroko,Edo, Kiyoto,Yamanaka, Hiroshi
, p. 3647 - 3656 (2007/10/02)
The influence of triphenylphosphine, used as a ligand, on the palladium-catalyzed cross-coupling reaction of iodopyrimidines with olefins such as ethyl acrylate, acrylonitrile, and styrene was investigated.In general, the addition of triphenylphosphine was concluded to retard the reaction in the pyrimidine series.The effect of triphenylphosphine in the monoazine series is also discussed.Keywords - palladium catalyst; carbon-carbon bond formation; homo-coupling reaction of N-heteroaromatic iodide; raction conditions; six-membered N-heteroaromatic iodide; substituted ethenylpyrimidine
Synthesis of pyrimidine derivatives having olefinic substituents by palladium-catalyzed cross-coupling reaction of iodopyrimidines
Sakamoto, Takao,Arakida, Hiroko,Edo, Kiyoto,Yamanaka, Hiroshi
, p. 965 - 968 (2007/10/02)
The palladium-catalyzed cross-coupling reactions of 2- and 4-iodopyrimidines with olefins were investigated on the stand-point of synthetic chemistry.The reaction was well catalyzed by use of palladium(II) acetate alone, palladium black, or palladium char
