84634-64-0

Basic information

• Product Name: 1,3-Propanedione, 1-(2-hydroxyphenyl)-3-(4-nitrophenyl)-
• CAS NO: 84634-64-0
• Molecular Formula: C15H11NO5
• Molecular Weight: 285.256
• Mol File: 84634-64-0.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 1,3-Propanedione, 1-(2-hydroxyphenyl)-3-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanedione, 1-(2-hydroxyphenyl)-3-(4-nitrophenyl)-(84634-64-0)
• EPA Substance Registry System: 1,3-Propanedione, 1-(2-hydroxyphenyl)-3-(4-nitrophenyl)-(84634-64-0)

Safety Data

• Hazardous Substances Data: 84634-64-0(Hazardous Substances Data)

Upstream product

• 36695-15-5 1-[2-(4-nitrobenzoyloxy)-phenyl]-ethanone 
• 122-04-3 4-nitro-benzoyl chloride 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 118-93-4 o-hydroxyacetophenone 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 854846-60-9 2-methyl-3-(4-nitrobenzoyl)-4H-chromen-4-one 
• 107641-20-3 3-(2-methoxyphenyl)-5-(4-aminophenyl)isoxazole 
• 107641-19-0 3-(2-methoxyphenyl)-5-(4-nitrophenyl)isoxazole 
• 107641-24-7 {4-[3-(2-Methoxy-phenyl)-isoxazol-5-yl]-phenyl}-[1-phenyl-meth-(E)-ylidene]-amine 
• 107641-21-4 2-({(E)-4-[3-(2-Methoxy-phenyl)-isoxazol-5-yl]-phenylimino}-methyl)-phenol 
• 107641-23-6 {4-[3-(2-Methoxy-phenyl)-isoxazol-5-yl]-phenyl}-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine 
• 107641-22-5 {4-[3-(2-Methoxy-phenyl)-isoxazol-5-yl]-phenyl}-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine 
• 902149-13-7 C₂₁H₁₃N₅O₇ 
• 256464-73-0 4'-nitro-4-thioflavone 
• 19725-49-6 4'-nitroflavone 
• 134051-34-6 1a,7a-Dihydro-1a-(4-nitrophenyl)-7H-oxireno<1>benzopyran-7-one 
• 153450-04-5 2-(4-Amino-phenyl)-3-bromo-chromen-4-one 
• 153450-08-9 2-(4-Hydrazino-phenyl)-chromen-4-one 

Relevant articles and documents

In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative

Chromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass

Design, synthesis and biological evaluation of 2-Phenyl-4H-chromen-4-one derivatives as polyfunctional compounds against Alzheimer’s disease

Polyfunctional compounds comprise a novel class of therapeutic agents for the treatment of multi-factorial diseases. A series of 2-Phenyl-4H-chromen-4-one and its derivatives (5a–n) were designed, synthesized, and evaluated for their poly-functionality against acetylcholinestrase (AChE) and advanced glycation end products (AGEs) formation inhibitors against Alzheimer’s disease (AD). The screening results showed that most of them exhibited a significant ability to inhibit AChE AGEs formation with additional radical scavenging activity. Especially, 5m, 5b, and 5j displayed the greatest ability to inhibit AChE (IC50 = 8.0, 8.2, and 11.8 nM, respectively) and AGEs formation (IC50 = 55, 79, and 54 μM, respectively) with good antioxidant activity. Molecular docking studies explored the detailed interaction pattern with active, peripheral, and mid-gorge sites of AChE. These compounds, exhibiting such multiple pharmacological activities, can be further taken a lead for the development of potent drugs for the treatment of Alzheimer’s disease.

Synthesis and anti-cancer activities of apigenin derivatives

A novel series of apigenin derivatives with phloroglucinol or resorcinol as raw materials were synthesized according to Baker-Venaktaraman reaction and their in vitro inhibitory activities on colorectal adenocarcinoma (HT-29) and leucocythemia (HL-60) cell lines were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The results of biological test showed that some of apigenin derivatives possessed stronger anti-cancer activities than apigenin. Compound 6 showed the strongest activity against colorectal adenocarcinoma (HT-29) and leucocythemia (HL-60) cell lines with IC50 valure of 2.03±0.22 μM, 2.25±0.42 μM, it was better than 5-FU (12.92±0.61 μM, 9.56±0.16 μM), which shows a potezntial compound for colorectal adenocarcinoma and leucocythemia.