84639-06-5

Basic information

• Product Name: ethyl 7-(benzyloxy)-1H-indole-2-carboxylate
• Synonyms: ethyl 7-(benzyloxy)-1H-indole-2-carboxylate;7-Benzyloxy-1H-indole-2-carboxylic acid ethyl ester
• CAS NO: 84639-06-5
• Molecular Formula: C₁₈H₁₇NO₃
• Molecular Weight: 295.33248
• Mol File: 84639-06-5.mol

Chemical Properties

• Melting Point: 82-83 °C(Solv: ethanol (64-17-5))
• Boiling Point: 481.4±30.0 °C(Predicted)
• Appearance: /
• Density: 1.225±0.06 g/cm3(Predicted)
• PKA: 14.37±0.30(Predicted)
• CAS DataBase Reference: ethyl 7-(benzyloxy)-1H-indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-(benzyloxy)-1H-indole-2-carboxylate(84639-06-5)
• EPA Substance Registry System: ethyl 7-(benzyloxy)-1H-indole-2-carboxylate(84639-06-5)

Safety Data

• Hazardous Substances Data: 84639-06-5(Hazardous Substances Data)

Upstream product

• 61535-21-5 1-(benzyloxy)-3-methyl-2-nitrobenzene 
• 917-58-8 potassium ethoxide 
• 95-92-1 oxalic acid diethyl ester 
• 96564-49-7 ethyl 3-(3-benzyloxy-2-nitrophenyl)-pyruvate, potassium salt 

Downstream Products

• 668968-89-6 7-Benzyloxy-1-methyl-1H-indole-2-carboxylic acid ethyl ester 
• 1207169-11-6 ethyl 7-benzyloxy-1-(2-trimethylsilylethoxymethyl)-1H-indole-2-carboxylate 
• 84639-19-0 7-(benzyloxy)-1-H-indole-2-carboxylic acid 
• 84638-99-3 methyl-3-(N-<2-oxo-2-(2-ethoxycarbinol-7-hydroxyindole-4-yl)-ethyl>-N-benzylamino)-butyrate, hydrochloride 
• 84638-81-3 methyl 4-(2-tert.-butylamino-1-hydroxyethyl)-7-hydroxyindole-2-carboxylate, hydrochloride 
• 84639-35-0 butyl 7-benzyloxyindole-2-carboxylate 
• 96564-48-6 methyl 7-(benzyloxy)-1H-indole-2-carboxylate 
• 84639-24-7 7-benzyloxy-1H-indole-2-carbonyl chloride 

Relevant articles and documents

A formal total synthesis of the telomerase inhibitor dictyodendrin B

A formal synthesis of the telomerase inhibitory marine pyrrolocarbazole alkaloid dictyodendrin B is described. The key features are consecutive palladium-catalyzed cross-coupling reactions and intramolecular reductive coupling reaction to construct the pyrrolo[2,3-c]carbazole framework.

Cytokine inhibitors

Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclos

Cytokine inhibitors

Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Indole derivatives pharmaceutical preparations based thereon, and β-receptor stimulation therewith

Indole derivatives of Formula I STR1 wherein R1 is hydrogen, alkyl of 1-6 carbon atoms, or benzyl R2 is hydrogen, alkyl of up to 4 carbon atoms, free or esterified hydroxyalkyl of up to 4 carbon atoms, or free, amidated or esterified

β2-Agonists containing metabolically labile groups. II. The influence of ester groups in the aryl system

β2-Agonists which are derived from alkyl 7-hydroxy-indole-2-carboxylates are highly active bronchodilators. The corresponding carboxylic acids, which can be formed metabolically from the esters, have diminished activity. Thus these compounds ar