846576-86-1

Basic information

• Product Name: Benzeneethanamine, N-[(4-bromophenyl)methyl]-b-phenyl-b-2-propenyl-
• CAS NO: 846576-86-1
• Molecular Formula: C24H24BrN
• Molecular Weight: 406.365
• Mol File: 846576-86-1.mol

Chemical Properties

• CAS DataBase Reference: Benzeneethanamine, N-[(4-bromophenyl)methyl]-b-phenyl-b-2-propenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanamine, N-[(4-bromophenyl)methyl]-b-phenyl-b-2-propenyl-(846576-86-1)
• EPA Substance Registry System: Benzeneethanamine, N-[(4-bromophenyl)methyl]-b-phenyl-b-2-propenyl-(846576-86-1)

Safety Data

• Hazardous Substances Data: 846576-86-1(Hazardous Substances Data)

Upstream product

• 53001-06-2 2,2-diphenyl-4-pentenylamine 
• 5558-71-4 2,2-diphenyl-pent-4-enenitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 86-29-3 Diphenylacetonitrile 

Downstream Products

• 1443233-51-9 1-(4-bromobenzyl)-3-chloro-5,5-diphenylpiperidine 

Relevant articles and documents

One-pot preparation of 3-chloropiperidine compounds via Cu(II)-promoted intramolecular chloroamination of unfunctionalized olefins

3-Chloropiperidine compounds were obtained via Cu(II)-promoted one-pot intramolecular chloroamination of N-benzyl-4-penten-1-amines and subsequent rearrangement. The reaction conditions leading to this skeleton were studied, and the structure of the product was confirmed by NMR as well as X-ray diffraction experiments.

A new method for intramolecular chloroamination of unfunctionalized olefins

A new method for the intramolecular chloroamination of unfunctionalized olefins is reported. The reactions were carried out at room temperature for 3 h using hydrated copper(II) chloride as both promoter and chlorine source, and the corresponding vincinal haloamines were obtained in good isolated yields.

Ligand acceleration in ZnI2-catalyzed intramolecular hydroamination of unfunctionalized olefins

Zinc halide-promoted hydroamination of 4-penten-1-amine compounds was studied. Preliminary results indicated that both steric and electronic factors are crucial for this Lewis acid-promoted reaction. ZnI2 gave the most promising results and the reactivity could be further increased upon addition of a suitable ligand. Up to 95% isolated yields were obtained when the reactions were carried out in 1,4-dioxane in the presence of 10 mol % of ZnI2 and 8-hydroxyquinoline.

Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines

Reaction of benzyl-2,2-diphenyl-4-pentenylamine with a catalytic 1:2 mixture of [PtCl2(H2C=CH2)]2 (2.5 mol %) and PPh3 in dioxane at 120 °C for 16 h led to isolation of 1-benzyl-2-methyl-4,4-diphenylp