846576-88-3

Basic information

• Product Name: Benzeneethanamine, N-[(4-nitrophenyl)methyl]-b-phenyl-b-2-propenyl-
• CAS NO: 846576-88-3
• Molecular Formula: C24H24N2O2
• Molecular Weight: 372.467
• Mol File: 846576-88-3.mol

Chemical Properties

• CAS DataBase Reference: Benzeneethanamine, N-[(4-nitrophenyl)methyl]-b-phenyl-b-2-propenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanamine, N-[(4-nitrophenyl)methyl]-b-phenyl-b-2-propenyl-(846576-88-3)
• EPA Substance Registry System: Benzeneethanamine, N-[(4-nitrophenyl)methyl]-b-phenyl-b-2-propenyl-(846576-88-3)

Safety Data

• Hazardous Substances Data: 846576-88-3(Hazardous Substances Data)

Upstream product

• 53001-06-2 2,2-diphenyl-4-pentenylamine 
• 555-16-8 4-nitrobenzaldehdye 
• 5558-71-4 2,2-diphenyl-pent-4-enenitrile 
• 86-29-3 Diphenylacetonitrile 

Downstream Products

• 1443233-52-0 1-(4-nitrobenzyl)-3-chloro-5,5-diphenylpiperidine 

Relevant articles and documents

Regioselective copper(II)-mediated bromoamination of unfunctionalized olefins: An efficient route to N-heterocyclic compounds

Bromoamination of unfunctionalized olefins was realized under mild conditions using copper(II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions could be carried out under open air at ambient temperature, and both N-alkylated and N-tosylated substrates could be converted to the corresponding N-heterocyclic compounds in high regioselectivity and good isolated yields. A variety of biologically important structures could be obtained via subsequent nucleophilic substitution reactions.

A new method for intramolecular chloroamination of unfunctionalized olefins

A new method for the intramolecular chloroamination of unfunctionalized olefins is reported. The reactions were carried out at room temperature for 3 h using hydrated copper(II) chloride as both promoter and chlorine source, and the corresponding vincinal haloamines were obtained in good isolated yields.

One-pot preparation of 3-chloropiperidine compounds via Cu(II)-promoted intramolecular chloroamination of unfunctionalized olefins

3-Chloropiperidine compounds were obtained via Cu(II)-promoted one-pot intramolecular chloroamination of N-benzyl-4-penten-1-amines and subsequent rearrangement. The reaction conditions leading to this skeleton were studied, and the structure of the product was confirmed by NMR as well as X-ray diffraction experiments.

Ligand acceleration in ZnI2-catalyzed intramolecular hydroamination of unfunctionalized olefins

Zinc halide-promoted hydroamination of 4-penten-1-amine compounds was studied. Preliminary results indicated that both steric and electronic factors are crucial for this Lewis acid-promoted reaction. ZnI2 gave the most promising results and the reactivity could be further increased upon addition of a suitable ligand. Up to 95% isolated yields were obtained when the reactions were carried out in 1,4-dioxane in the presence of 10 mol % of ZnI2 and 8-hydroxyquinoline.

Platinum-catalyzed intramolecular hydroamination of unactivated olefins with secondary alkylamines

Reaction of benzyl-2,2-diphenyl-4-pentenylamine with a catalytic 1:2 mixture of [PtCl2(H2C=CH2)]2 (2.5 mol %) and PPh3 in dioxane at 120 °C for 16 h led to isolation of 1-benzyl-2-methyl-4,4-diphenylp