84688-79-9Relevant academic research and scientific papers
Triaminotriazine DNA helicase inhibitors with antibacterial activity
McKay, Geoffrey A.,Reddy, Ranga,Arhin, Francis,Belley, Adam,Lehoux, Dario,Moeck, Greg,Sarmiento, Ingrid,Parr, Thomas R.,Gros, Philippe,Pelletier, Jerry,Far, Adel Rafai
, p. 1286 - 1290 (2007/10/03)
Screening of a chemical library in a DNA helicase assay involving the Pseudomonas aeruginosa DnaB helicase provided a triaminotriazine inhibitor with good antibacterial activity but associated cytotoxicity toward mammalian cells. Synthesis of analogs provided a few inhibitors that retained antibacterial activity and demonstrated a significant reduction in cytotoxicity. The impact of serum and initial investigations toward a mode of action highlight several features of this class of compounds as antibacterials.
