84695-64-7Relevant academic research and scientific papers
Feasibility of an immunoassay for mevalonolactone
Spencer, Thomas A.,Clark, Dawn S.,Johnson, Gary A.,Erickson, Sandra K.,Curtiss, Linda K.
, p. 873 - 882 (1997)
Mevalonic acid is a key intermediate in a broad spectrum of cellular biological processes and their regulation. Availability of a rapid, sensitive and accurate method for its assay would be highly useful. Therefore, the feasibility of developing an immuno
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity
Nicolaou, K. C.,Stepan, Antonia F.,Lister, Troy,Li, Ang,Montero, Ana,et al.
supporting information; experimental part, p. 13110 - 13119 (2009/03/12)
The molecular design, chemical synthesis, and biological evaluation of two distinct series of platensimycin analogues with varying degrees of complexity are described. The first series of compounds probes the biological importance of the benzoic acid subunit of the molecule, while the second series explores the tetracyclic cage domain. The biological data obtained reveal that, while the substituted benzoic acid domain of platensimycin is a highly conserved structural motif within the active compounds with strict functional group requirements, the cage domain of the molecule can tolerate considerable structural modifications without losing biological action. These findings refine our present understanding of theplatensimycin pharmacophore and establish certain structure-activity re lationships from which the next generation of designed analogues of thisnew antibiotic may emerge.
Mn(III)-based C-C bond formation: Regioselective α′-allylation of various α,β-unsaturated, α and β-alkoxy α,β-unsaturated ketones
Tanyeli, Cihangir,?zdemirhan, Devrim
, p. 8212 - 8217 (2007/10/03)
The Manganese(III)-based regioselective α′-keto radical generation of unsaturated ketones is a versatile synthetic procedure with broad applicability. The generated α′-keto radical slowly creates a metal enolate in a solvent at reflux. The resultant metal
Mn(III)-mediated radical C-C bond formation: Regioselective α′-allylation of α,β-unsaturated ketones
Tanyeli, Cihangir,?zdemirhan, Devrim
, p. 3977 - 3980 (2007/10/03)
Mn(OAc)3-mediated regioselective α′-allylation of α,β-unsaturated enones is described. α′-Allyl α,β-unsaturated enones are obtained through a radical process in good yields.
ORGANOMANGANESE (II) REAGENTS XVI: COPPER-CATALYZED 1,4-ADDITION OF ORGANOMANGANESE CHLORIDES TO CONJUGATED ENONES
Cahiez, Gerard,Alami, Mouad
, p. 3541 - 3544 (2007/10/02)
Copper-catalyzed conjugate addition of organomanganese chlorides to conjugated enones in THF, at 0 deg C, leads to the 1,4-addition products in high yields.The scope of the reaction is very large and the results are generally better than those obtained from organomagnesium compounds in the presence of a copper salts as well as from organocopper or cuprate reagents.Furthermore organomanganese chlorides are indisputably cheaper and more stable than the latter.
Alkoxides as Nucleophiles in (?-Allyl)palladium Chemistry. Synthetic and Mechanistic Studies
Stanton, Susan A.,Felman, Steven W.,Parkhurst, Carol S.,Godleski, Stephen A.
, p. 1964 - 1969 (2007/10/02)
A new methodology for the use of alkoxides as nucleophiles in (?-allyl)palladium chemistry has been developed.In this process an allylic alcohol serves as the precursor to the ?-allyl complex and a triethylsilyl (TES) ether as precursor to the alkoxide nucleophile.By using Pd(PPh3)4 in CCl4, PPh3Cl+CCl3- is generated transposing the ROH into an oxyphosphonium group, R-O-P+Ph3, and liberating Cl-.The Cl deprotects the TES ether, providing the nucleophile in situ.Application of this reaction to the preparation of a variety of furans is discussed.This process was determined to proceed with overall predominant retention of configuration.Mechanistic studies suggest a small energy difference between attack by alkoxide on the allyl ligand of the intermediate complex and attack on the metal, followed by reductive elimination.
