847021-17-4

Basic information

• Product Name: 2-(3-{5-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione
• CAS NO: 847021-17-4
• Molecular Weight: 499.547
• Mol File: 847021-17-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-{5-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-{5-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione(847021-17-4)
• EPA Substance Registry System: 2-(3-{5-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione(847021-17-4)

Safety Data

• Hazardous Substances Data: 847021-17-4(Hazardous Substances Data)

Upstream product

• 103-85-5 monophenylthiourea 
• 17823-27-7 2-(phenylimino)thiazolidin-4-one 
• 123-08-0 4-hydroxy-benzaldehyde 
• 847020-99-9 2-(3-{4-Oxo-2-[(E)-phenylimino]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione 
• 94205-70-6 5-(4-hydroxybenzyliden)-2-(phenylimino)thiazolidin-4-one 
• 5181-36-2 N-<(3-bromopropyl)oxy>phthalimide 

Relevant articles and documents

Synthesis and biological evaluation of 7-N-(n-alkoxyphthalimido)-2hydroxy- 4-aryl-6-aryliminothiazolidino [2,3-b] pyrimidines and related compounds

Substituted aryl thioureas 1a-c react with chloroacetic acid in the presence of anhydrous sodium acetate to furnish 2-aryliminothiazolidin-4-ones 2a-c. Condensation of ω-bromoalkoxyphthalimides 3a-c with 2a-c give the corresponding alkoxyphthalimide derivatives of 2-aryliminothiazolidin-4-ones 4a-i. These on condensation with araldehydes 5a-c yield 3-N-(alkoxyphthalimido)- 5-arylidene-2-aryliminothiazolidin-4-ones 7a-a′. In an alternative route 5a-c react with 2a-c to give 6a-i, which could be cyclised with urea in the presence of sodium acetate to yield the corresponding thiazolidinopyrimidine 8a-i. 7a-a′ are also prepared from 6a-i with 3a-c, which give final compound 9a-a′ on cyclisation. Alternatively, 8a-i when condensed with 3a-c also furnish the compounds 9a-a′. Evaluation of antimalarial and antibacterial activity is also reported.