847157-49-7Relevant academic research and scientific papers
Macrocyclic inhibitors of β-secretase: Functional activity in an animal model
Stachel, Shawn J.,Coburn, Craig A.,Sankaranarayanan, Sethu,Price, Eric A.,Pietrak, Beth L.,Huang, Qian,Lineberger, Janet,Espeseth, Amy S.,Jin, Lixia,Ellis, Joan,Holloway, M. Katharine,Munshi, Sanjeev,Allison, Timothy,Hazuda, Daria,Simon, Adam J.,Graham, Samuel L.,Vacca, Joseph P.
, p. 6147 - 6150 (2007/10/03)
A macrocyclic inhibitor of β-secretase was designed by covalently cross-linking the P1 and P3 side chains of an isophthalamide-based inhibitor. Macrocyclization resulted in significantly improved potency and physical properties when compared to the initia
MACROCYCLIC BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 10; 20, (2008/06/13)
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is a
