50765-19-0

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-IODO-5-NITRO-BENZOATE is used as a building block in organic synthesis for the development of various pharmaceuticals. Its unique functional groups make it a valuable intermediate in the synthesis of new drugs and medicinal compounds.
Used in Agrochemical Industry:
METHYL 3-IODO-5-NITRO-BENZOATE is also used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products.
Used in Organic Synthesis:
METHYL 3-IODO-5-NITRO-BENZOATE is utilized as an important intermediate for the synthesis of various organic compounds, enabling the creation of a wide range of chemical products through its versatile functional groups.

InChI:InChI=1/C8H6INO4/c1-14-8(11)5-2-6(9)4-7(3-5)10(12)13/h2-4H,1H3

Upstream product

• 618-95-1 methyl 3-nitrobenzoate 
• 121-92-6 3-nitrobenzoic acid 
• 23218-93-1 3-amino-5-nitro-benzoic acid methyl ester 
• 99-34-3 3,5-dinitrobenzoic acid 
• 79-37-8 oxalyl dichloride 
• 6313-17-3 3-iodo-5-nitro-benzoic acid 
• 67-56-1 methanol 

Downstream Products

• 144949-58-6 5,5'-dinitro-1,1'-biphenyl-3,3'-dicarboxylic acid dimethyl ester 
• 50765-23-6 3-Hydroxy-5-iodbenzylalkohol 
• 50765-21-4 3-hydroxy-5-iodobenzoic acid 
• 50765-22-5 methyl 3-hydroxy-5-iodobenzoate 
• 1000587-40-5 3-(5-methyl-pyridin-2-yl)-5-nitrobenzoic acid methyl ester 
• 1000587-41-6 3-amino-5-(5-methylpyridin-2-yl)benzoic acid methyl ester 
• 1639866-71-9 3-ethynyl-5-nitrobenzoic acid 
• 1639866-72-0 3-amino-5-ethynylbenzoic acid 
• 847157-51-1 C₂₅H₃₀N₂O₅S 
• 1000587-71-2 3-(1-chloro-2,2-difluoro-propylideneamino)-5-(5-methylpyridin-2-yl)benzoic acid methyl ester 
• 1000587-49-4 3-(4-methyl-2-oxo-2H-pyridin-1-yl)-5-tetrazol-1-yl-benzoic acid 
• 1000587-48-3 3-(4-methyl-2-oxo-2H-pyridin-1-yl)-5-tetrazol-1-yl-benzoic acid methyl ester 
• 1000587-47-2 3-amino-5-(4-methyl-2-oxo-2H-pyridin-1-yl)benzoic acid methyl ester 
• 1000587-43-8 3-(5-methylpyridin-2-yl)-5-tetrazol-1-yl-benzoic acid 

Relevant academic research and scientific papers

Design of photoaffinity labeling probes derived from 3,4,5-trimethylfuran-2(5H)-one for mode of action elucidation

Herein we report the synthesis of new probes for photoaffinity labeling with the aim of receptor identification and mode of action elucidation of 3,4,5-trimethylfuran-2(5H)-one (TMB), recently identified in the smoke of burning vegetation as an efficient seed germination inhibitor. These photoaffinity probes consist of an ethynyl group that acts as a tag for introduction of an optional detectable marker unit by an appropriate chemoselective ligation method after the photo-cross-linking operation.

TETRAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.

THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula 1: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF

Compounds are provided according to formula (I), where A, B, W, X', L, R1, R3, R4b, and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

Imidazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.

Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.