84716-73-4

Basic information

• Product Name: (4-methoxyphenyl)(5,6,7-trimethoxyisoquinolin-1-yl)methanone
• Synonyms: (4-Methoxyphenyl)(5,6,7-trimethoxy-1-isoquinolinyl)methanone; methanone, (4-methoxyphenyl)(5,6,7-trimethoxy-1-isoquinolinyl)-
• CAS NO: 84716-73-4
• Molecular Formula: C₂₀H₁₉NO₅
• Molecular Weight: 353.3686
• Mol File: 84716-73-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 530.6°C at 760 mmHg
• Flash Point: 274.7°C
• Density: 1.214g/cm³
• Vapor Pressure: 2.42E-11mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: (4-methoxyphenyl)(5,6,7-trimethoxyisoquinolin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxyphenyl)(5,6,7-trimethoxyisoquinolin-1-yl)methanone(84716-73-4)
• EPA Substance Registry System: (4-methoxyphenyl)(5,6,7-trimethoxyisoquinolin-1-yl)methanone(84716-73-4)

Safety Data

• Hazardous Substances Data: 84716-73-4(Hazardous Substances Data)

Usage

General Description

The chemical compound "(4-methoxyphenyl)(5,6,7-trimethoxyisoquinolin-1-yl)methanone" is a complex molecule containing both a methoxyphenyl group and a trimethoxyisoquinolin-1-yl group. The methoxyphenyl group consists of a phenyl ring with a methoxy (CH3O) group attached at the 4th position, while the trimethoxyisoquinolin-1-yl group is a derivative of the isoquinoline with three methoxy groups attached at the 5th, 6th, and 7th positions. The molecule also contains a methanone functional group. (4-methoxyphenyl)(5,6,7-trimethoxyisoquinolin-1-yl)methanone may have applications in the field of organic synthesis, pharmaceuticals, or medicinal chemistry, but further research and study would be necessary to determine its specific properties and potential uses.

Upstream product

• 47439-73-6 5,6,7-trimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline 
• 5489-20-3 (4-methoxyphenyl)(5,6,7-trimethoxy-3,4-dihydroisoquinolin-1-yl)methanone 
• 3937-16-4 2-(2,3,4-trimethoxyphenyl)ethylamine 
• 13664-92-1 2,2-dibromo-1-(4-methoxyphenyl)ethanone 
• 36982-71-5 5,6,7-trimethoxyisoquinoline 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Novel total syntheses of oxoaporphine alkaloids enabled by mild Cu-catalyzed tandem oxidation/aromatization of 1-Bn-DHIQs

Novel total syntheses of oxoaporphine alkaloids such as liriodenine, dicentrinone, cassameridine, lysicamine, oxoglaucine and O-methylmoschatoline were developed. The key step of these total syntheses is Cu-catalyzed conversion of 1-benzyl-3,4-dihydro-isoquinolines (1-Bn-DHIQs) to 1-benzoyl-isoquinolines (1-Bz-IQs) via tandem oxidation/aromatization. This novel Cu-catalyzed conversion has been studied in detail, and was successfully used for constructing the 1-Bz-IQ core.

A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines

Methoxy- and benzyloxy-substituted isoquinolines are regioselectively metalated at C-1 with the Knochel-Hauser base, subsequent trapping with aromatic aldehydes gives aryl(isoquinolin-1-yl)carbinols as building blocks for divergent syntheses of different types of benzylisoquinoline alkaloids. Photochemical cyclization of ortho-bromo analogues under reductive conditions gives oxoaporphine alkaloids. Nine benzylisoquinoline alkaloids and two oxoaporphine alkaloids were obtained in two or three steps from appropriate isoquinolines.

Synthesis of isoquinoline alkaloids via oxidative amidation-bischler- napieralski reaction

A straightforward synthesis of -keto amides by coupling primary amines with aryl dibromoethanones under oxidative amidation conditions has been developed. The -keto amides were then subjected to heterocyclodehydration reaction under Bischler-Napieralski conditions followed by aromatization with DBU provided 1-benzoyl isoquinolines in a two-stage process. Utilizing this methodology, isoquinoline alkaloids such as thalmicrinone, papavaraldine, and pulcheotine A were synthesized in excellent yields. Georg Thieme Verlag Stuttgart · New York.