84718-05-8

Upstream product

• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 263908-63-0 (+/-)-((Z)-3-(butyltellanyl)-1-phenyl-allyloxy)(tert-butyl)dimethylsilane 
• 145450-43-7 2-Methylidene-1-phenyl-1-<(tert-butyldimethylsilyl)oxy>but-3-ene 
• 1240492-43-6 (+/-)-4,4,5,5-tetramethyl-2-((1S,2R)-2-phenylcyclopropyl)-1,3,2-dioxaborolane 
• 1240492-43-6 racemic 4,4,5,5-tetramethyl-2-((1S,2S)-2-phenylcyclopropyl)-1,3,2-dioxaborolane 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 1177092-75-9 (3Z,1R,2S)-1,2-diphenylhex-3-en-1-ol 
• 1613220-70-4 1-phenyl-1-(tert-butyldimethylsiloxy)-3-(trimethylgermyl)-2-propyne 
• 17329-15-6 1,6-diphenyl-1,3,5-hexatriene 
• 1613220-72-6 1-phenyl-3-(trimethylgermyl)-2-propen-1-ol 
• 1613220-58-8 (E)-1-phenyl-3-(trimethylgermyl)allyl acetate 
• 1613220-71-5 1-phenyl-3-(trimethylgermyl)prop-2-yn-1-ol 

Relevant academic research and scientific papers

A Vinyl-Boronate Ester-Based Persulfide Donor Controllable by Hydrogen Peroxide, a Reactive Oxygen Species (ROS)

A vinyl boronate ester-based persulfidating agent that is selectively activated by hydrogen peroxide, which is a reactive oxygen species (ROS), and efficiently generated a persulfide by a hitherto unexplored 1,4-O,S-relay mechanism is reported. This donor was found to protect cells from cytotoxicity induced by oxidants, and the major byproduct is cinnamaldehyde, which is widely used in the food industry as an additive.

One-Pot, Three-Step Synthesis of Cyclopropylboronic Acid Pinacol Esters from Synthetically Tractable Propargylic Silyl Ethers

Simple propargylic silyl ethers can be converted to complex cyclopropylboronic acid pinacol esters in an efficient one-pot procedure. Terminal acetylenes undergo a Schwartz's reagent catalyzed hydroboration; subsequent addition of further Schwartz's reage

Gold-Catalyzed Intramolecular Tandem Cyclization of Indole-Ynamides: Diastereoselective Synthesis of Spirocyclic Pyrrolidinoindolines

A gold-catalyzed intramolecular tandem cyclization of indole-ynamide affords tetracyclic spirocyclic pyrrolidinoindoline bearing an all-carbon quaternary stereocentre in a single step; however, when the reaction was carried out in the presence of BF3·Et2O, the corresponding tricyclic spirocyclic pyrrolidinoindoline-based enones are produced through a key 1,5-hydride shift. The developed chemistry provides a diastereoselective and straightforward entry to structurally diverse polycylic pyrrolidinoindolines from indole-ynamides in one-pot reactions under mild conditions.

Iodine-promoted silylation of alcohols with silyl chlorides. Synthetic and mechanistic studies

An efficient silylating system for 1°, 2°, and 3° alcohols, consisting of a silyl chloride/N-methylimidazole/iodine, was developed. Synthetic and mechanistic aspects of this new reagent system, and particularly the role of iodine were investigated in detail using 1H NMR spectroscopy.

A chemoselective deprotection of trimethylsilyl acetylenes catalyzed by silver salts

Trimethylsilyl acetylenes can be selectively deprotected in the presence of a catalytic amount of silver salts. AgNO3 and AgOTf proved to be the most effective catalyst in a mixture of methanol, water and dichloromethane. Other functional groups, and especially silyl ethers, are not affected in these conditions.

Palladium-catalyzed silastannation of secondary propargylic alcohols and their derivatives

A series of terminal propargylic alcohols and their derivatives were subjected to Pd-catalyzed silastannation. In all reactions, complete regio- and stereoselectivities were observed with the tributyltin moiety exclusively adding to the internal carbon of the triple bond in a cis fashion, including the first example of a diyne bis-silastannation. Silastannation reaction products could sequentially be protiodesilylated or iododestannylated, thus providing synthetic routes to 1,1-gem-disubstituted alkenylstannanes and iodides, respectively.

[3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties

Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) STR1 as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 is hydroxy; R2 is hydrogen; or R1 and R2 together are an oxo group; R3 is STR2 wherein A is --CH2 --CH2 --; trans--CH=CH--; --C C--; and R4 is linear or branched alkyl of one to twelve carbons, preferably 1-10 carbons, most preferably 3-8 carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or phenylloweralkyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo.

(3.2.0) Bicycloheptanone oxime ethers with therapeutic properties

Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) STR1 as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 is hydroxy; R2 is hydrogen; or R1 and R2 together are an oxo group; R3 is STR2 wherein A is --CH2 --CH2 --; trans-CH=CH--; --C C--; and R4 is linear or branched alkyl of one to twelve carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or optionally substituted phenylalkyl.