24016-11-3Relevant academic research and scientific papers
N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4- carboxamide compounds useful as hiv integrase inhibitors
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Page/Page column 18; 25, (2010/11/27)
N-Benzyl-dihydroxypyridine carboxamide compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dihydroxypyridine carboxamides are of Formula (I) wherein Q is Formula (II) or Formula (III); T is Formula (IV); and R1, R2, X1,X2,X3, and Y1 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
STUDY OF THE CATALYTIC PROPERTIES OF TRIS (3,6-DIOXAHEPTYL)AMINE (TDA-1) IN HETEROAROMATIC NUCLEOPHILIC SUBSTITUTION OF CHLOROPYRIDINES AND THEIR N-OXIDES
Ballesteros, P.,Claramunt, R.M.
, p. 2557 - 2564 (2007/10/02)
Catalytic properties of tris(3,6-dioxaheptyl)amine (TDA-1) have been analyzed in reactions of alkoxydehalogenation of 2- and 4-chloropyridine and their N-oxides under solid-liquid phase transfer catalysis conditions.Alkoxypyridines were obtained in excellent yields but with N-oxides a competitive alkaline cleavage of the performed ether was observed.
