Cas 847246-73-5,5-(4-chlorophenyl)-7-(2,6-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine

847246-73-5

Post Buying Request

Basic information

Product Name: 5-(4-chlorophenyl)-7-(2,6-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine
Synonyms: 5-(4-chlorophenyl)-7-(2,6-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine
CAS NO:847246-73-5
Molecular Formula:
Molecular Weight: 377.66
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 5-(4-chlorophenyl)-7-(2,6-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine(CAS DataBase Reference)
NIST Chemistry Reference: 5-(4-chlorophenyl)-7-(2,6-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine(847246-73-5)
EPA Substance Registry System: 5-(4-chlorophenyl)-7-(2,6-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine(847246-73-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 847246-73-5(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products
Article

847246-73-5 Suppliers

Recommended suppliers

847246-73-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 847246-73-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,7,2,4 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 847246-73:
(8*8)+(7*4)+(6*7)+(5*2)+(4*4)+(3*6)+(2*7)+(1*3)=195
195 % 10 = 5
So 847246-73-5 is a valid CAS Registry Number.

847246-73-5Upstream product

847246-73-5Downstream Products

847246-73-5Relevant academic research and scientific papers

Inhibitors of secretion of hepatitis B virus antigens

-

Page/Page column 15; 16, (2017/01/26)

Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.

Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion

Yu, Wenquan,Goddard, Cally,Clearfield, Elizabeth,Mills, Courtney,Xiao, Tong,Guo, Haitao,Morrey, John D.,Motter, Neil E.,Zhao, Kang,Block, Timothy M.,Cuconati, Andrea,Xu, Xiaodong

, p. 5660 - 5670 (2011/10/08)

The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals play an important role in suppressing HBV-specific immune response and are only mildly affected by the current small molecule therapies. Thus, a therapy that specifically reduces HBsAg serum levels could be used in combination therapy with nucleos(t)ide drugs or permit therapeutic vaccination for the treatment of HBV infection. Herein, we report the design, synthesis, and evaluation of novel triazolo-pyrimidine inhibitors (1, 3, and 4) of HBsAg cellular secretion, with activity against drug-resistant HBV variants. Extensive SAR led to substantial improvements in the EC50 of the parent compound, 5 (HBF-0259), with the best being 3c, with EC50 = 1.4 ± 0.4 μM, SI ≥ 36. The lead candidates, both 1a (PBHBV-001) and 3c (PBHBV-2-15), were well-tolerated in both normal and HBV-transgenic mice and exhibited acceptable pharmacokinetics and bioavailability in Sprague-Dawley rats.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 847246-73-5