847259-60-3

Upstream product

• 161374-07-8 ethyl 4-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one-5-carboxylate 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1311274-12-0 N'-(5-cyano-1-methyl-6-oxo-4-phenylpyrimidin-2-yl)-4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide 
• 1311274-15-3 C₂₅H₂₂N₈O₆ 
• 1311274-14-2 C₂₆H₂₅N₇O₅ 
• 1311274-13-1 C₂₅H₂₂ClN₇O₄ 

Relevant academic research and scientific papers

Microwave assisted synthesis and pharmacological screening of novel 6-Methyl-2-oxo-4-substituted 5-(5-Phenyl-1,3,4-oxadiazole-2-yl)-1,2,3, 4-tetrahydropyrimidines

A simple and efficient method has been developed for the synthesis of various 1,3,4-oxadiazole derivatives prepared from DHPM using microwave irradiation technique. The series of 1,3,4-oxadiazole-2-yl-1,2,3,4- tetrahydropyrimidine-2(1H)-one derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for there lipoxygenase inhibitory and antibacterial activities. The results showed that this skeletal framework exhibited marked potency as lipoxigenase inhibition and antibacterial agents. The most active lipoxigenase inhibitor and antibacterial agent was 6-methyl-2-oxo-4-(p-nitrophenyl)-5-(5-phenyl-1,3,4-oxadiazole-2-yl)-1,2,3,4- tetrahydropyrimidine.

Synthesis and antimicrobial screening of some substituted INH and THPHM linked pyrimidines

Several 6-(substituted)-5-cyano-2-methylthio-3-N-methyl-3,4- dihydropyrimidin-4-ones (1a-e) were treated with isonicotinic acid hydrazide and 4-anisyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide to get (2a-d) and (3a-d). Compounds were ch