84729-97-5

Upstream product

• 5158-64-5 2,3,4-tri-O-acetyl-D-fucopyranosyl bromide 
• 824-78-2 4-nitrophenol sodium salt 
• 100-02-7 4-nitro-phenol 
• 73-34-7 D-Fucose 
• 51921-33-6 1,2,3,4-tetra-O-acetyl-D-fucopyranose 

Downstream Products

• 1226-39-7 p-nitrophenyl-β-D-fucopyranoside 
• 84730-04-1 p-nitrophenyl 2-O-(2,3,4-tri-O-acetyl-α-L-fucopyranosyl)-β-D-fucopyranoside 
• 84730-05-2 p-nitrophenyl 2-O-(2,3,4-tri-O-acetyl-β-L-fucopyranosyl)-β-D-fucopyranoside 
• 84730-06-3 p-nitrophenyl 2-O-β-L-fucopyranosyl-β-D-fucopyranoside 
• 81329-62-6 p-nitrophenyl 2-O-α-L-fucopyranosyl-β-D-fucopyranoside 
• 84730-02-9 p-nitrophenyl 3,4-O-isopropylidene-2-O-(2,3,4-tri-O-acetyl-L-fucopyranosyl)-β-D-fucopyranoside 
• 84730-01-8 p-nitrophenyl 2,4-di-O-acetyl-β-D-fucopyranoside 
• 84729-99-7 p-nitrophenyl 2-O-acetyl-3,4-O-isopropylidene-β-D-fucopyranoside 
• 84730-00-7 p-nitrophenyl 2-O-acetyl-β-D-fucopyranoside 
• 84729-98-6 p-nitrophenyl 3,4-O-isopropylidene-β-D-fucopyranoside 

Relevant academic research and scientific papers

Glycosynthase with broad substrate specificity-an efficient biocatalyst for the construction of oligosaccharide library

A versatile glycosynthase (TnG-E338A) with strikingly broad substrate scope has been developed from Thermus nonproteolyticus β-glycosidase (TnG) by using site-directed mutagenesis. The practical utility of this biocatalyst has been demonstrated by the facile generation of a small library containing various oligosaccharides and a steroidal glycoside (total 25 compounds) in up to 100 % isolated yield. Moreover, an array of eight gluco-oligosaccharides has been readily synthesized by the enzyme in a one-pot, parallel reaction, which highlights its potential in the combinatorial construction of a carbohydrate library that will assist glycomic and glycotherapeutic research. Significantly, the enzyme provides a means by which glycosynthase technology may be extended to combinatorial chemistry.