1154870-59-3

Basic information

• Product Name: Tert-butyl3-hydroxycyclopentylcarbamate
• Synonyms: Tert-butyl3-hydroxycyclopentylcarbamate;tert-butyl(3-hydroxycyclopentyl)catbaMte;tert-butyl N-(3-hydroxycyclopentyl)carbamate;tert-Butyl (3-hydroxycyclopentyl)
• CAS NO: 1154870-59-3
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26276
• Mol File: 1154870-59-3.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 320.8±31.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.27±0.40(Predicted)
• CAS DataBase Reference: Tert-butyl3-hydroxycyclopentylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-butyl3-hydroxycyclopentylcarbamate(1154870-59-3)
• EPA Substance Registry System: Tert-butyl3-hydroxycyclopentylcarbamate(1154870-59-3)

Safety Data

• Hazardous Substances Data: 1154870-59-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl3-hydroxycyclopentylcarbamate is a chemical compound with the molecular formula C10H19NO3. It is a carbamate derivative, with a tert-butyl group and a hydroxycyclopentyl group attached to the carbamate functional group. Tert-butyl3-hydroxycyclopentylcarbamate is used in the synthesis of pharmaceuticals and agrochemicals as a building block for the construction of more complex molecules. It is important for its potential biological activities, and has been studied for its potential application in the development of new drugs and agricultural products. Tert-butyl3-hydroxycyclopentylcarbamate is a colorless, highly viscous liquid at room temperature and is stable under normal conditions.

Upstream product

• 108-05-4 vinyl acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 542-92-7 cyclopenta-1,3-diene 
• 126924-22-9 (1S,4R,αR-)-3-(α-hydroxyphenylacetyl)-2-oxa-3-aza-bicyclo[2,2,1]hept-5-ene 
• 154802-92-3 tert-butyl cis-N-[4-hydroxycyclopent-2-en-1-yl]carbamate 
• 60217-34-7 lithium tri-sec-butyl(hydrido)borate 
• 167298-40-0 tert-butyl (S)-(3-oxocyclopentyl)carbamate 
• 193751-54-1 tert-butyl cyclopent-3-en-1-ylcarbamate 
• 847416-99-3 tert-butyl N-(3-oxocyclopentyl)carbamate 
• 930-30-3 cyclopent-2-enone 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 2487-95-8 4-Isocyanato-cyclopentene 
• 1154870-59-3 (+/-)-cis-(3-hydroxy-cyclopentyl)-carbamic acid tert-butyl ester 
• 250659-32-6 racemic tert-butyl ((1R,3S,5S)-6-oxabicyclo[3.1.0]hexan-3-yl)carbamate 

Downstream Products

• 946593-67-5 (1S,3S)-3-aminocyclopentan-1-ol 
• 1197398-99-4 racemic cis-(3-amino-cyclopentyl)-carbamic acid tert-butyl ester 
• 1197398-99-4 (±)-(anti)-(3-amino-cyclopentyl)-carbamic acid tert-butyl ester 
• 1154870-59-3 (±)-trans-(3-hydroxycyclopentyl)carbamic acid tert-butyl ester 
• 1197398-99-4 tert-butyl N-[trans-3-aminocyclopentyl]carbamate 
• 1197398-99-4 C₁₀H₂₀N₂O₂ 
• 847416-99-3 tert-butyl N-(3-oxocyclopentyl)carbamate 

Relevant articles and documents

Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs

Benzimidazole and indane are the two key fragments in our potent and selective MCH-1 receptor (MCHR1) antagonists. To identify novel linkers connecting the two fragments, we investigated diamino-cycloalkane-derived analogs and discovered highly potent antagonists with cis-1,4-diaminocyclohexane as a unique spacer in this chemical class. Structural overlay suggested that cis-1-substituted-4-aminocyclohexane functions as a bioisostere of 4-substituted-piperidine and that the active conformation adopts a U-shaped orientation.

KRAS G12C Inhibitor compound and application thereof

The invention provides a KRAS G12C inhibitor compound and an application thereof, and particularly provides a compound as shown in a formula (I), and an optical isomer, a hydrate, a solvate or pharmaceutically acceptable salt thereof. The compound can be used as a KRAS G12C inhibitor and is used for treating diseases related to the activity or expression quantity of KRAS G12C.

Intermediate for preparing bictegravir and preparation method thereof

The invention relates to the technical field of a drug, and concretely relates to an intermediate for preparing bictegravir and a preparation method thereof. The present invention provides two novel types of compounds and three routes for preparation of a compound (VI). Through substrate induction, chiral catalysis or synergistic effect of substrate induction and chiral catalysis, the stereoselectivity of a Diels-Alder reaction can be greatly improved, and a high chiral purity of a common intermediate (III) can be obtained; cut-out of N-O bond and reduction the double bond use catalytic hydrogenation, which can be environmentally friendly; the reaction conditions are mild, the yield is higher than the existing preparation method, the method is economic and effective, and is adapted to large-scale industrial production.