84755-29-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-[2-(methylthio)-5-pyrimidinyl](9CI) is used as a potential drug candidate for its potential applications in drug development. Its unique structure and properties may contribute to the creation of new therapeutic agents.
Used in Agricultural Chemicals:
Ethanone, 1-[2-(methylthio)-5-pyrimidinyl](9CI) is used as a potential component in the development of agricultural chemicals, where its properties could be harnessed for pest control or crop protection.
Used in Biochemistry and Pharmacology Research:
Ethanone, 1-[2-(methylthio)-5-pyrimidinyl](9CI) is used as a research tool in biochemistry and pharmacology, where it can aid in understanding the mechanisms of action and interactions of various biological systems. Further studies may reveal additional potential uses and applications for Ethanone, 1-[2-(methylthio)-5-pyrimidinyl]- (9CI) in various fields of science and technology.

Upstream product

• 4338-95-8 S-methylthiouronium iodide 
• 84755-27-1 (Z)-4-ethoxy-3-formyl-3-buten-2-one 
• 14001-67-3 5-bromo-2-methylthiopyrimidine 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 122476-79-3 2-methylthio-5-trimethylstannylpyrimidine 
• 75-36-5 acetyl chloride 
• 917-54-4 methyllithium 
• 110099-95-1 2-(methylthio)pyrimidine-5-carbonyl chloride 

Downstream Products

• 87573-88-4 5-acetyl-2(1H)-pyrimidinone 
• 110100-06-6 5-acetyl-1-benzyl-2(1H)-pyrimidinone 
• 87573-90-8 5-(1-chlorolvinyl)-2-pyrimidinone 
• 87573-81-7 5-ethynyl-2-methylthiopyrimidine 
• 120717-48-8 5-(1-chloroethyl)-2-(methylthio)pyrimidine 
• 120717-49-9 5-(1-fluoroethyl)-2-methylthiopyrimidine 
• 87573-79-3 5-(1-chlorovinyl)-2-methylthiopyrimidine 

Relevant academic research and scientific papers

NOVEL GPR119 AGONIST COMPOUNDS

The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.

Synthesis of 5-Stannylpyrimidines and their Use in Pd-Catalysed Ketone Formation

2-(Dimethyl-t-butylsiloxy)-5-stannylpyrimidines have been prepared from the lithiated pyrimidine precursor. 2-Methylthio-5-stannylpyrimidines were prepared similarly and oxidized chemoselectively to the corresponding sulphones. 5-Stannylpyrimidin-2(1H)-ones can be prepared by fluoride-induced removal of the silyl group in 2-(dimethyl-t-butylsiloxy)-5-stannylpyrimidines, and the 5-stannylated pyrimidinones can be N-alkylated.The stannylated pyrimidines are stable compounds which react readily with acid chlorides in Pd-catalysed reaction with formation of 5-pyrimidinyl ketones.

Organomanganese(II) Reagents in the Synthesis of 5-Pyrimidinyl Ketones

Substituted alkyl 5-pyrimidinyl ketones were formed from acid chlorides of pyrimidine-5-carboxylic acids and alkylmanganese(II) iodides.The corresponding alcohols were also formed in the case of sterically less requiring organomanganese reagents and the a

Enols of 1,1-Diformylacetone in the Synthesis of 5-Acylpyrimidines

The enol acetate of 3-oxobutanal has been formylated using ethyl orthoformate to provide the enol ether of 1,1-diformylacetone.The latter has been condensed with methylisothiourea to yield isomeric 5-acetyl and 4-methyl-5-formyl- pyrimidines, the ratio being dependent on the reaction conditions.