84758-85-0Relevant academic research and scientific papers
Polymer-bound N-hydroxysuccinimide as a solid-supported additive for DCC-mediated peptide synthesis
Chinchilla, Rafael,Dodsworth, David J.,Nájera, Carmen,Soriano, José M.
, p. 4487 - 4489 (2001)
Polymer-supported N-hydroxysuccinimide (P-HOSu) has been prepared from a styrene/maleic anhydride co-polymer and used as an easily removable activating and racemization-reducing additive for the peptide coupling of amino acid derivatives using DCC.
Microwave-enhanced solution coupling of the α,α-dialkyl amino acid, Aib
Santagada, Vincenzo,Fiorino, Ferdinando,Perissutti, Elisa,Severino, Beatrice,De Filippis, Vincenzo,Vivenzio, Beniamino,Caliendo, Giuseppe
, p. 5171 - 5173 (2007/10/03)
The difficult coupling of α-aminoisobutyric acid (Aib), during the synthesis of dipeptides (1-6), was carried out using PyBOP/HOBt and HBTU/HOBt reagents by application of microwave energy in the presence of solvent. Room temperature, conventional heating
Oxidation-induced Acyl group transfer from hydroquinone esters to nucleophiles
Reischl, Gerald,El-Mobayed, Medhat,Bei?wenger, Rudolf,Regier, Klaus,Maichle-M?ssmer, C?cilia,Rieker, Anton
, p. 765 - 773 (2007/10/03)
Bivalent oxidation of 3,5-di-tert-butyl-hydroquinone monoesters leads to phenoxenium ions, which can transfer an acyl group to nucleophiles. Based on this principle, dipeptides, glyco-amino acids and N-sulfonyl-amino acids were synthesized from hydroquino
SYNTHESE VON 2-METHYLALANIN-PEPTIDEN, DIE pH-ABHAENGIGKEIT IHRER 13C-NMR-SPECTREN UND EINE NEUE METHODE ZUR AUSWERTUNG UEBER CS-DIAGRAMME
Leibfritz, Dieter,Haupt, Erhard,Dubischar, Norbert,Lachmann, Heinrich,Oekonomopulos, Raymond,Jung, Guenther
, p. 2165 - 2182 (2007/10/02)
The uncommon amino-acid 2-methylalanine (α-aminoisobutiryc acid, Aib) was investigated by 13C-NMR.The chemical shifts of amino- or carboxy-protected derivates of Aib and of protected oligopeptides are discussed with respect to neighbouring groups and amino acids.The pH-dependence of the 13C-NMR spectra of Aib, Aib-Ala, Ala-Aib, Aib-Ala-Aib and Aib-Ala-Aib-Ala-Aib was studied.Using these examples, a new and advantageous method is demonstrated for the first time for the evaluation of NMR titration curves, which uses so-called chemical shift diagrams (CS diagrams).
