84765-90-2Relevant academic research and scientific papers
PHTHA OYL GROUP: A NEW AMINO PROTECTING GROUP OF DEOXYADENOSINE IN OLIGONUCLEOTIDE SYNTHESIS
Kume, Akiko,Sekine, Mitsuo,Hata, Tsujiaki
, p. 4365 - 4368 (1982)
A phthaloyl group has been introduced into the N6-amino group of deoxyadenosine via silylation followed by acylation.The phthaloyl group resulted in remarkable retarding effects on depurination, while it could be removed under milder conditions than the benzoyl group.Thus, a tetradeoxy-adenylate has been successfully synthesized in high yield.
