PHTHA OYL GROUP: A NEW AMINO PROTECTING GROUP OF DEOXYADENOSINE IN OLIGONUCLEOTIDE SYNTHESIS

DOI: 10.1016/S0040-4039(00)85601-4

Source and publish data:

Tetrahedron Letters p. 4365 - 4368 (1982)

Update date:2022-09-26

Topics:

Authors:

Kume, Akiko

Sekine, Mitsuo

Hata, Tsujiaki

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Article abstract of DOI:10.1016/S0040-4039(00)85601-4

A phthaloyl group has been introduced into the N⁶-amino group of deoxyadenosine via silylation followed by acylation.The phthaloyl group resulted in remarkable retarding effects on depurination, while it could be removed under milder conditions than the benzoyl group.Thus, a tetradeoxy-adenylate has been successfully synthesized in high yield.

Full text of DOI:10.1016/S0040-4039(00)85601-4

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