84765-99-1

Upstream product

• 1462-75-5 3-phenylpropylmagnesium bromide 
• 84765-96-8 6-chloro-9-(2,3,5-tris-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl)-9H-purine 

Relevant academic research and scientific papers

SYNTHESIS OF 6-ALKYL AND 6-ARYL SUBSTITUTED 9-β-D-RIBOFURANOSYL PURINES VIA THE NICKEL CATALYZED COUPLING OF GRIGNARD REAGENTS TO 2',3',5'-Tris-O-(t-BUTYLDIMETHYLSILYL)-9-β-D-RIBOFURANOSYL-6-CHLOROPURINE

A series of 6-substituted purine nucleosides have been synthesized in moderate yield by the nickel catalyzed cross coupling reaction between alkyl- and aryl-Grignard reagents and 2',3',5'-tris-O-(t-butyldimethylsilyl)-9-β-D-ribofuranosyl-6-chloropurine.