SYNTHESIS OF 6-ALKYL AND 6-ARYL SUBSTITUTED 9-β-D-RIBOFURANOSYL PURINES VIA THE NICKEL CATALYZED COUPLING OF GRIGNARD REAGENTS TO 2',3',5'-Tris-O-(t-BUTYLDIMETHYLSILYL)-9-β-D-RIBOFURANOSYL-6-CHLOROPURINE

Article abstract of DOI:10.1016/S0040-4039(00)88701-8

A series of 6-substituted purine nucleosides have been synthesized in moderate yield by the nickel catalyzed cross coupling reaction between alkyl- and aryl-Grignard reagents and 2',3',5'-tris-O-(t-butyldimethylsilyl)-9-β-D-ribofuranosyl-6-chloropurine.