467217-77-2

Upstream product

• 98-86-2 acetophenone 
• 73843-97-7 (E)-3-(ethylthio)-3-(methylamino)-1-phenylprop-2-en-1-one 
• 37510-42-2 3,3-bis(ethylthio)-1-phenylprop-2-en-1-one 
• 65-85-0 benzoic acid 

Downstream Products

• 847778-81-8 5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-4-trimethylsilanyl-pyridine-2-carboxylic acid methyl ester 
• 847778-83-0 5-(2-tert-butoxy-1-methoxycarbonyl-ethylthiocarbamoyl)-6-phenyl-pyridine-2-carboxylic acid methyl ester 
• 847778-82-9 5-(2-tert-butoxy-1-methoxycarbonyl-ethylcarbamoyl)-6-phenyl-pyridine-2-carboxylic acid methyl ester 
• 847778-84-1 5-((R)-4-Methoxycarbonyl-4,5-dihydro-thiazol-2-yl)-6-phenyl-pyridine-2-carboxylic acid methyl ester 
• 847778-79-4 (S)-2-((Z)-3-Amino-3-phenyl-acryloylamino)-3-tert-butoxy-propionic acid methyl ester 
• 847778-78-3 3-tert-butoxy-2-(3-oxo-3-phenyl-propionylamino)-propionic acid methyl ester 

Relevant academic research and scientific papers

Practical Synthesis of β-Ketothioesters by Acid-Catalyzed Hydrolysis of Ketene N,S-Acetals with Amino as the Leaving Group

A Novel, general, and highly efficient methodology for the synthesis of β-ketothioesters from ketene N,S-acetals has been developed. In this acid-catalyzed reaction, the amino group, including both alkylamino and arylamino groups, of α-oxo ketene N,S-acetals can be easily displaced in the presence of H2O as nucleophile (hydrolysis) instead of the alkylthiol group reported. This new method is simple and practical. A series of β-ketothioesters were prepared in high yields with broad tolerance of substrates under mild reaction conditions.

DBSA-catalyzed hydrolysis of chain α-oxo ketene dithioacetals in water: Aqueous synthesis of β-ketothioesters

In this paper, we wish to report an environment friendly synthetic method for β-ketothioesters from a dodecylbenzenesulfonic acid (DBSA)-catalyzed hydrolysis reaction of chain α-oxo ketene dithioacetals in water. It was shown that the hydrolysis reaction of chain α-oxo ketene dithioacetals could efficiently occur in the presence of 7.5 mol% DBSA at 100 °C in water, affording the desired β-keto thioesters in excellent yields.

One-pot multistep Bohlmann-Rahtz heteroannulation reactions: Synthesis of dimethyl sulfomycinamate

(Chemical Equation Presented) The synthesis of dimethyl sulfomycinamate, the acidic methanolysis product of the sulfomycin family of thiopeptide antibiotics, from methyl 2-oxo-4-(trimethylsilyl)but-3-ynoate is achieved in a 2,3,6-trisubstituted pyridine synthesis that proceeds with total regiocontrol in 13 steps by the Bohlmann-Rahtz heteroannulation of a 1-(oxazol-4-yl)enamine or in 12 steps and 9% yield by three-component cyclocondensation with N-[3-oxo-3-(oxazol-4-yl)propanoyl]serine and ammonia in ethanol.